均匀设计法优选玄麝止痛巴布剂基质配方研究  

Optimization of Matrix Prescription and Preparation Process of Xuanshe Painkillers Cataplasm Using Uniform Design

作　　者：薛宝娟[1] 龙致贤[1] 王玉蓉[1] 

机构地区：[1]北京中医药大学,北京100102

出　　处：《中药新药与临床药理》2008年第6期499-501,共3页Traditional Chinese Drug Research and Clinical Pharmacology

摘　　要：目的优选玄麝止痛巴布剂最佳基质配方。方法采用均匀设计法,以黏着力和外观(膜残留、均匀性、涂展性、追随性)为主要考察指标,对巴布剂基质配方进行优选,以确定最佳制备工艺。结果通过实验数据分析,优选出各基质最佳比例为:NP-700∶氢氧化铝∶甘油∶0.1%酒石酸水溶液=3∶0.3∶25∶5。结论优选所得基质黏着力适中,无膜残留,均匀性、涂展性、皮肤追随性均较好,制备工艺良好。Objective To optimize the formula ratio of matrix and the preparation process of Xuanshe Painkillers Cataplasm. Methods The optimal matrix prescription of Xuanshe Painkillers Cataplasm was optimized by uniform design, and the optimal preparation process was determined at the same time. The viscosity and the appearance of the Xuanshe Painkillers Cataplasm （film residue, uniformity, ductility, skin adhesive ability of the plaster）are used as indexes. Results The preparation process of Xuanshe Painkillers Cataplasm is good, and through the analysis of experimental data, the optimal ratio of the matrix is NP - 700 ： aluminum hydroxide ： glycerol ： 0. 1% tartrate solution = 3 ： 0. 3 ： 25 ： 5. Conclusion The Preparation process is good and the optimal matrix has moderate viscosity, no film residue, and with better uniformity, ductility and skin adhesive ability.

关 键 词：玄麝止痛巴布剂 均匀设计 基质配方 制备工艺 

分 类 号：R284.2[医药卫生—中药学]