经颅多普勒超声动态监测对多发性脑梗塞认知障碍的应用价值  

The value of dynamic determining of hematic dynamics for cognitive impairment ofpatient s with multi-infarction

作　　者：顾克金[1] 李跃群[1] 李宪章[1] 张爱梅[1] 

机构地区：[1]济宁医学院附属医院神经内科,山东济宁272029

出　　处：《中国医疗前沿（学术版）》2008年第9期13-14,38,共3页China Healthcare Innovation

基　　金：山东省卫生厅保健委资助(2005044)

摘　　要：目的探讨动态监测脑血流动力学参数对早期发现多发性脑梗塞病人认知障碍的应用价值。方法用TCD、P300、MMSE对多发性脑梗塞(MI)病人进行动态观察。结果对无痴呆的135例MI病人动态随访,每3月一次共2年,多发性脑梗塞性痴呆(MID)发生率为21.5%(29/135),其中的22例发生于随访的1年后,占75.9%(22/29);随访中出现痴呆的病人Vm逐渐降低,RI逐渐增高,与单纯MI组相比,两组从6-9个月开始即显示出明显的差异,较MID的发生高峰提前3-6个月。结论用TCD动态监测MI病人的平均血流速度和阻力指数,对早期发现多发性脑梗塞病人认知障碍有重要价值。Objective to evaluate the value of dynamic determining of hematic dynamics for cognitive impairment of patients with multi-infarct. Methods Patients with MI were determined regularly every 3 months with TCD,P300 and MMSE as far as 24 months. Results Among 135 cases with MI 29 cases were diagnosed as MID （21.5%） during the period of 24 months, in which 22 cases developed as patients with MID in the second year of foUow-up （86.1%）.Between those patients with and without dementia, significance was found in Vm and RI and it was 3-6 months before cognitive impairment appeared.Conclusion It is valuable to determine Vm and RI regularly for early diagnosis of cognitive impairment of patients with multi-infarction.

关 键 词：经颅多普勒超声 动态监测 认知障碍 早期诊断 

分 类 号：R743.3[医药卫生—神经病学与精神病学]