中国人群肺癌发病危险因素的Meta分析  

META-ANALYSIS OF THE RISK FACTOR OF LUNG CANCER AMONG CHINESE PEOPLE

作　　者：王文雷[1] 付莉[2] 崔亚玲[3] 陆维权[3] 

机构地区：[1]郑州大学公共卫生学院,郑州450001 [2]郑州铁路职业技术学院 [3]河南省肿瘤研究所

出　　处：《现代预防医学》2008年第22期4336-4338,共3页Modern Preventive Medicine

摘　　要：[目的]探讨中国人群肺癌发生的主要危险因素,为预防决策提供依据。[方法]利用Meta分析方法对我国1995～2007年间公开发表的有关肺癌危险因素病例对照研究的12篇文献资料进行定量综合分析。[结果]各因素合并OR值及95%CI分别为:吸烟OR=2.7820(2.3428～3.3035);油烟OR=2.6257(1.7312～3.9879);家族肿瘤史OR=1.8075(1.4745～2.2157);肺结核OR=2.6018(1.8946～3.5731);慢性支气管炎OR=2.3052(1.8013～2.9500);精神因素OR=2.2648(1.8364～2.7932);饮酒OR=1.4942(1.2491～1.7873);被动吸烟OR=1.7064(0.9109～3.1965);新鲜蔬菜OR=0.5376(0.4445～0.6503)。[结论]吸烟、饮酒、油烟、家族肿瘤史、肺结核、慢性支气管炎、精神因素是目前中国人群肺癌发病的危险因素;而多吃新鲜蔬菜是肺癌发生的保护性因素。[Objective ] To explore the main risk factors related to the incidence of lung cancer among Chinese people so as to provide basis for decision making on lung cancer prevention. [Methods] 12 published literatures of case-control studies on risk factor of lung cancer from 1995 to 2007 were collected and analyzed synthetically by Meta-analysis. [ ReSults] The pooled odds radio values and 95%CI were： smoking OR=2.7820 （2.3428-3.3035）; cooking smoking OR=2.6257 （1.7312- 3.9879） ; Family history of tumor OR =1.8075 （1.4745-2,2157） ; pulmonary tuberculosis OR =2.6018 （ 1.8946-3.5731 ） ; chronic bronchitis OR=2.3052 （1.8013-2.9500） ; mentality OR=202648 （1.8346-2.7932） ） ; alcohol drinking OR=1.4942 （1.2491-1.7873） ; exposure to environmental tobacco smoking OR=1.7064 （0.9109-3.1965） ; and fresh vegetables OR=0.5376 （0.4445-0.6503）. [ Conclusion] The risk factors influencing the incidence of lung cancer in Chinese people were smoking, alcohol drinking, cooking smoking, family history, of tumor, pulmonary tuberculosis, chronic bronchitis, mentality and so on, while fresh vegetables were the protectoral factors.

关 键 词：肺癌 危险因素 病例对照 META分析 

分 类 号：R734.2[医药卫生—肿瘤]