基质金属蛋白酶7在非小细胞肺癌中表达的临床意义  

Clinical significance expression of MMP-7 in patients with primary non-small cell lung cancer

作　　者：韩福才[1] 单彬彬[1] 程小珍[1] 朱海波[1] 郭伟[1] 郭沁香[1] 田瑞芬[1] 苏文忠[1] 

机构地区：[1]山西省肿瘤医院呼吸科,太原030013

出　　处：《肿瘤研究与临床》2008年第11期743-744,748,共3页Cancer Research and Clinic

摘　　要：目的研究基质金属蛋白酶7（MMP-7）在非小细胞肺癌（NSCLC）组织中的表达，探讨MMP-7与NSCLC患者临床病理特征的关系。方法用RT—PCR技术检测20名健康人外周血标本及60例晚期NSCLC患者的外周血标本，凝胶图像分析仪分析MMP-7结果。结果健康人外周血中的MMP-7（30．000）显著低于NSCLC患者外周血中的MMP-7（41．231）（P〈0．05）；MMP-7在NSCLC组织中的表达与患者性别、病理类型、肿瘤瘤体大小无关（P〉0．05）；与肺癌组织分化程度呈负相关（P〈0．05），与临床分期呈正相关（P〈0．05）。结论研究表明MMP-7是判断NSCLC侵袭转移生物学行为的一个好的标志物。Objective To study the relationship between expression of matrix metalloproteinases-7 （MMP-7） and elinieopathologieal characteristics in patients with primary non-small cell lung caneer（NSCLC）. Methods MMP-7 in 20 normal people and 60 advanced NSCLC patiens were detected with reverse- transeription-polymerase-ehain-reaction. Gelatum image analysator analyzed the result. Results The amount of MMP-7 was less in normal people （30.000） than in NSCLC patients（41.231） signifieantly（P 〈0.05）; the level of MMP-7 was no correlated with gender, age, pathology pattern, tumor size, was inverse correlation with differentiation, and was positive correlation with clinical stages（P 〈0.05）. Conclusion The level of MMP-7 is closely correlated with tissue differentiation and clinical stages of NSCLC, which may serve as a parameter for determining tumor invasion and metastatic.

关 键 词：癌 非小细胞肺 基质金属蛋白酶7 

分 类 号：R734[医药卫生—肿瘤]