肺癌磁共振扩散加权成像与肿瘤细胞密度的相关性研究  

Correlation between magnetic resonance diffusion weighted imaging and cellular density in lung cancer

作　　者：刘振生[1] 李澄[1] 陈建[1] 何玲[1] 杜芳[1] 王苇[1] 罗志刚[1] 薛贞龙[1] 赵义[1] 周长武[1] 

机构地区：[1]扬州市第一人民医院放射科,江苏扬州225001

出　　处：《生物医学工程与临床》2008年第6期474-477,共4页Biomedical Engineering and Clinical Medicine

摘　　要：目的利用表观扩散系数(ADC)来评价肺癌的组织学特征。方法28例肺癌患者,其中男性18例,女性10例,年龄25～79岁,平均年龄52岁。行扩散加权成像(DWI)检查并测量病灶的ADC,方差分析比较不同组织学类型肺癌ADC间的差别。对11例外科切除的肺癌病灶ADC与细胞密度进行相关性分析。结果鳞癌、腺癌、小细胞癌平均ADC分别为(1.67±0.20)×10-3mm2/s、(2.08±0.28)×10-3mm2/s、(1.76±0.21)×10-3mm2/s,腺癌的ADC明显高于鳞癌及小细胞癌(P<0.05)。肺癌ADC与细胞密度呈显著负相关(r=-0.71,P=0.015)。结论腺癌的ADC明显高于其他类型肺癌;ADC似乎可以鉴别肺癌的组织学类型。Objective To evaluate histologic characteristics of lung cancer by apparent diffusion coefficient （ADC）. Methods A total of 28 patients with lung cancer,male 18 ,female 10,aged 25 - 79 years,mean age 52 years ,were performed magnetic resonance diffusion weighted imaging （DWI） and ADC of each lung cancer patient was calculated. Analysis ofvariance was used to determine changes in ADC of lung carcinoma histological types. Of the patients, 11 surgically excised lung cancers were evaluated for correlation between ADC and tumor cellular density. Results The ADC of lung cancer were （ 1.67 ± 0.20） ×10^-3mm2/s for squamous carcinoma, （2.08 ± 0.28） ×10^-3 mm2/s for adenocarcinoma and （1.76 ± 0.21） ×10^-3 mm2/s for small cell carcinoma respectively. The ADC of adenocarcinoma was significantly higher than that of squamous carcinoma and small cell carcinoma（P〈 0.05）. The ADC of lung cancer was correlated with tumor cellular density significantly （r = -0.71,P = 0.015 ）. Conclusion The ADC of adenocarcinoma is higher than that ofother histological type lung cancers and ADC might be used to differentiate various histological type lung cancers.

关 键 词：肺癌 磁共振成像 扩散加权成像:细胞密度 

分 类 号：R734.2[医药卫生—肿瘤]