VEGF映射ROP新生血管的初步研究  

Preliminary research of VEGF mapped ROP neovascularization

作　　者：李斌[1] 李艳会[2] 徐玲娟[1] 华开罗 

机构地区：[1]华中科技大学同济医学院同济医院眼科,中国湖北省武汉市430030 [2]中山大学数学与计算科学学院,中国广东省广州市510275 [3]中国湖北省中山医院消化内科,430033

出　　处：《国际眼科杂志》2008年第11期2187-2188,共2页International Eye Science

基　　金：中国国家自然科学基金资助项目(No.30672278,30872823);中国湖北省自然科学基金资助项目(No.2007ABA108)~~

摘　　要：目的:利用VEGF的变化映射早产儿视网膜病变新生血管的发生发展过程。方法:建立缺氧小鼠新生血管动物模型,实时定量PCR检测小鼠视网膜VEGF在不同时间点的mRNA值,通过函数绘制VEGF与新生血管的拟合曲线,并求得VEGF映射视网膜新生血管的函数方程。结果:通过实验和数学推算,我们获得VEGF映射视网膜新生血管的线性方程。结论:利用VEGF的mRNA表达,可以建立方程映射视网膜新生血管的发生发展,为下一步研究奠定基础。AIM： To map the development and progression of retinopathy neovascularization of prematurity by the changes of VEGF. METHODS. Animal model of high oxygen inducing retinal neovascularizaton was established. The mRNA level of VEGF in mice retinal at different time points was assayed by real time PCR. Then we drew the Fitting curve of VEGF and angiogenesis by function, access to function equation of VEGF mapped retinal neovascularization. RESULTS. We get Linear equations of VEGF to map retinal neovascularization. CONCLUSION- We can create equations to map retinal neovascularization by mRNA expression level of VEGF and lay the foundation for further study.

关 键 词：VEGF 映射 视网膜 新生血管 

分 类 号：R774.1[医药卫生—眼科] R735.7[医药卫生—临床医学]