Hedgehog信号通路与胃肠道肿瘤的相关性研究进展  

Advances in research on relationship between Hedgehog signal pathway and gastroenteric tumor

作　　者：戴磊[1] 李继坤[1] 

机构地区：[1]上海交通大学附属上海市第一人民医院普外科,上海200080

出　　处：《中国癌症杂志》2008年第11期857-861,共5页China Oncology

摘　　要：作为重要的内胚层分子信号,Hedgehog(HH)基因家族在胃肠道的发育中发挥重要作用,胚胎发育如果缺乏HH信号调控,将会出现多种胃肠道畸形:而在成熟个体中,洲在消化道的特定部位也有正常表达,这与消化道正常功能的维持可能相关。然而,越来越多的研究显示,HH信号通路与多种消化道肿瘤的发生、发展存在紧密联系,并且不同的消化道肿瘤中HH通路所起的作用不尽一致,其机制并不相同。本文将在胃、结直肠癌方面就近年来HH信号通路的研究进展作一综述。Hedgehog（HH）, a vital endodermal signal, plays a critical role in the embryonic development of the GI system. During mammalian embryonic development, deficiency of HH signaling leads to gastrointestinal malformations. Nevertheless, normal presence of HH family is also found in the adult gut,and HH signaling now may be important for homeostasis of the gut in such a case. However, many researches revealed that the HH signal＇s involved in gastrointestinal carcinogenesis and its role is altered in various tumors due to various mechanisms. This review focused on the progress of HH signal pathway in gastrointestinal tumors.

关 键 词：胃癌 结直肠癌 HEDGEHOG WNT TGF-Β 

分 类 号：R730.231.9[医药卫生—肿瘤]