抑郁症患者脑源性神经营养因子基因位点多态性与负性生活事件的相关性研究——附85例报告  

Interaction of brain-derived neurotrophic factor genetic polymorphisms and negative life events in patients with depressive disorders

作　　者：吴天文[1] 杨蓓[1] 蔡少荣[1] 崔才三[1] 

机构地区：[1]山东大学齐鲁医院神经内科,250012

出　　处：《新医学》2008年第11期710-712,共3页Journal of New Medicine

摘　　要：目的：探讨脑源性神经营养因子（brain-derived neurotrophic factor,BDNF）基因G196A位点多态性与抑郁症患者负性生活事件的相关性。方法：对85例抑郁症患者（抑郁症组）和158名健康人（对照组）进行BDNF基因G196A基因型检测和生活事件量表（life events scale,LES）评分,比较2组的结果,分析G196A位点多态性与负性生活事件的相关性。结果：抑郁症组的LES中总生活事件、负性生活事件、正性生活事件评分均高于对照组。抑郁症组G等位基因频率为70%（119/170）、A等位基因频率为30%（51/170）;对照组相应为51.3%（162/316）、48.7%（154/316）,2组比较差异有统计学意义（P〈0.05）。抑郁症组G等位基因频率与负性生活事件呈正相关（P〈0.05,优势比为3.102,95%可信区间为1.118-8.609）;A等位基因频率与负性生活事件呈负相关（P〈0.05,优势比2.962,95%可信区间为1.038-8.451）。结论：BDNF基因G196A位点G等位基因可能是抑郁症患者对负性生活事件敏感的遗传基础。Objective： To investigate an interaction between the genetic polymorphisms （G196A） of brain-derived neurotrophic factor （BDNF） and negative life events in patients with depressive disorders. Methods： Genotype of 85 depressive disorders patients （DD group） and 158 healthy controls （control group） were identified by polymerase chain reaction （PCR）. Life events were evaluated using a life events scale （LES） , the results of two groups were compared. An interaction of BDNF genetic polymorphisms and negative life events was analyzed. Results： The LES scale （ including total life scales, negative life scales and positive life scales） were significant higher in DD group than in control group. The frequencies of G and A allele were respectively 70% （119/170） and 30% （ 51/170） in DD group, 51.3 % （ 162/316 ） and 48.7% （ 154/316） in control group （ P 〈 0.05 ）. The data showed a significant positive correlation between frequencies of G allele and negative life events （P 〈 0. 05, odds ratio 3. 102, 95% confidence interval 1.118 - 8. 609 ）, and a significant negative correlation between frequencies of A allele and negative life events （ P 〈 0. 05, odds ratio 2. 962, 95% confidence interval 1. 038 - 8.451 ） in DD group. Conclusion： G allele of BDNF gene G196A may be a hereditary basis on higher sensitivity of negative life events in patients with depressive disorders.

关 键 词：抑郁症 脑源性神经营养因子 基因 基因多态性 负性生活事件 

分 类 号：R749.4[医药卫生—神经病学与精神病学]