粘蛋白与干眼症  

Mucins and dry eye

作　　者：蔡蓉蓉[1] 张朝然[1] 

机构地区：[1]复旦大学附属眼耳鼻喉科医院眼科,上海200031

出　　处：《眼科研究》2008年第11期877-880,共4页Chinese Ophthalmic Research

摘　　要：眼表粘蛋白由角膜、结膜、泪器产生,是泪膜的重要成分,具有稳定泪膜、保护眼表、参与信号转导等功能。干眼症中粘蛋白的量和结构均发生改变,是干眼症发病机制的中间环节,同时也是结果之一。干眼症中眼表粘蛋白的检测可能具有潜在的诊断价值。促进粘蛋白分泌或表达的药物将成为治疗干眼症的重要手段。就眼表粘蛋白及其在干眼症中的表达变化做一综述。Mucins produced by conjunctiva,cornea and lacrimal apparatus are important components of preocular tear film,and they play important roles in tear film stabilization,ocular surface protection and intracellular signal transduction.Mucins decrease and alter in structures in dry eye syndrome,which is an intermediate mechanism of dry eye,and also one of the consequences.Assay of preocular mucins may have potential values for diagnosis of dry eye.Pharmacologic agents that can facilitate secretion or expression of mucins will be important therapeutics for dry eye.

关 键 词：泪膜 粘蛋白 干眼症 

分 类 号：R777[医药卫生—眼科]