A型肉毒素治疗痉挛型脑瘫临床观察  

Clinical Observation of the Therapeutic Effect of BTXA in Cerebral Palsy

作　　者：董小丽[1] 孔勉[1] 余志华[1] 伍蓉梅[1] 刘巍[1] 

机构地区：[1]四川省成都市第一人民医院儿童康复中心,四川成都610017

出　　处：《华西医学》2008年第4期844-845,共2页West China Medical Journal

基　　金：国家自然科学基金项目(NO90209013;30371709);四川省卫生厅资助项目(NO070348)

摘　　要：目的:探讨肉毒毒素A(BTXA)注射配合康复训练对痉挛型脑瘫患儿运动功能及日常生活活动能力(activities of daily living,ADL)的影响。方法:选择例100例双下肢痉挛型脑瘫儿童随机分为BTX-A组和对照组各50例,2组均采用常规康复训练,A型肉毒毒(botulinumtoxin A,BTX2A)组加用兰州产BTX-A干粉制剂,(于-20^-5℃避光保存,以生理盐水稀释后立即使用),运用"反向牵拉指压法"进行下肢痉挛肌局部注射,注射后次日开始进行痉挛肌牵伸及功能训练。观察两组患儿的肌张力与ADL变化。结果:治疗1个月和3个月后,治疗组患儿的肌张力、ADL改善情况明显优于对照组(P<0.01)。结论:康复训练仍是有效的脑瘫治疗手段,BTX-A注射配合康复训练可明显改善痉挛型脑瘫患儿运动功能和日常生活能力。两者结合可明显缩短疗程、提高疗效。Objective：To discuss the therapeutic effect of BTXA in treating cerebral palsy baby.Method：100 patients were randomly divides into two groups,the BTX-A group and control group each 50 patients,two groups also use the conventional recovery training,the BTX2A group adds the BTX-A dried noodles,carries on the injection with pulls the finger-pressing to the lower limb convulsion partial,after the injection,the next day to start to carry on the convulsion the faculty training.Observestwo groups of baby＇s muscle tension and the ADL change.Result：Treats 1 month and 3 months later,the treatment group baby＇s muscle tension and the ADL improvement situation surpass the antitheses group obviously（P〈0.01）.Conclusion：The recovery training was still the effective to cerebral palsy treatment method,the BTX-A injection coordination recovery training might improve the convulsion cerebral palsy movement function and activities of daily living obviously.The two methods may reduce the treatment course,enhance the curative effect obviously.

关 键 词：脑性瘫痪 肉毒素A 痉挛 日常生活活动能力 

分 类 号：R742.3[医药卫生—神经病学与精神病学]