脑出血患者血肿周围脑组织水通道蛋白-4的表达变化  

The Change of aquaporin-4 Expression in Perihematomal Tissue of Intracerebral Hemorrhage Patients

作　　者：程桂玲[1] 吕涌涛 迟兆富[2] 

机构地区：[1]山东省交通医院,250031 [2]山东大学齐鲁医院,250012

出　　处：《中国临床神经科学》2008年第6期585-589,共5页Chinese Journal of Clinical Neurosciences

基　　金：山东省交通厅资助项目(2005Y026);山东省科技厅资助项目(2006GG 2302052)

摘　　要：目的:探讨脑出血血肿周围脑组织水通道蛋白-4(AQP4)的表达规律及其与脑水肿形成的关系。方法:32例行颅内血肿清除术患者,按发病至手术时间不同分为<6 h、6～24 h、24～72 h和>72 h组。取术中获得的脑组织做病理标本,检测AQP4的表达变化,并观察其组织病理及超微结构变化。结果:<6 h组脑组织轻微水肿,AQP4表达呈弱阳性,6 h后水肿逐渐加重,AQP4表达开始增强,至24～72 h达高峰。此后,AQP4表达下降,水肿减轻。结论:脑出血后AQP4表达呈动态变化与脑组织水肿程度一致,提示AQP4在脑出血患者脑水肿的发生、发展中起着重要作用。Aim： To investigate the relationship between the expression of aquaporin-4（AQP4） and cerebral edema formation in perihematomal tissue of hypertensive intracerebral hemorrhage patients. Methods： 32 patients with hypertensive intracerebral hemorrhage were selected and divided into 〈6 h, 6- 24 h, 24- 72 h and 〉72 h groups according to the time from the onset of illness to operation. Perihematomal brain tissues were obtained in the course of hematoma elimination. The change of aquaporin-4 expression was evaluated while the pathological and ultrastructural changes of the brain tissue were respectively observed. Results：The brain tissues within 6 hours group were slightly damaged and the expression of AQP-4 was slightly positive, severely damaged and gradually increased of the AQP-4 expression after 6 hours of intracerebral hemorrhage,and got to the maximum between 24-72 h. After 72 h of intracerebral hemorrhage, the expression of AQP4 was gradually decreased and the brain edema was improved. Conclusion：The dynamic change of aquaporin-4 expression can be observed in perihematomal tissue of intracerebral hemorrhage patients and is closely associated with the level of cerebral edema, suggesting that AQP-4 should play an important role in the course of the occurrence and development of the hemorrhagic cerebral edema.

关 键 词：高血压脑出血 水通道蛋白-4 脑水肿 血肿 

分 类 号：R743[医药卫生—神经病学与精神病学]