^125I粒子组织间植入对裸鼠食管癌移植瘤的影响  

The effect of interstitial brachytherapy with ^125I on esophageal carcinoma in nude mice

作　　者：包海标[1] 孙常波[1] 吕宾[1] 孟立娜[1] 倪桂宝[2] 麻林爱[2] 

机构地区：[1]浙江中医药大学附属第一医院消化科,杭州310006 [2]浙江中医药大学附属第一医院病理科,杭州310006

出　　处：《中华消化内镜杂志》2008年第11期597-600,共4页Chinese Journal of Digestive Endoscopy

基　　金：浙江省科技厅科技项目（2006C33068）

摘　　要：目的研究^125I放射性粒子组织间植入对于食管癌移植瘤的影响。方法将人食管癌细胞Eca-109注入裸鼠腋侧皮下建立食管癌裸鼠移植瘤模型，随机分成对照组（生理盐水＋空心粒子）、^125I粒子组（剂量22．2MBq×1）和顺铂组（1mg/kg）。观察人食管癌移植瘤的生长情况和病理学改变。结果术后16d，对照组、^125I粒子组、顺铂组的瘤块平均重量分别为（0．20±0．06）g，（0．12±0．03）g，（0．12±0．05）g，3组间差异有统计学意义（P〈0．05）。病理结果，^125I粒子组、顺铂组镜下可见变性、坏死的食管癌肿瘤细胞。^125I粒子组、顺铂组肿瘤组织坏死范围大于对照组（P〈0．05）。结论^125I粒子植入可以引起食管癌移植瘤肿瘤组织变性、坏死，抑制肿瘤组织的生长。Objective To investigate the effeet of interstitial brachytherapy with 12st on human esophageal carcinoma implanted in nude mice. Methods Animal model simulating human esophageal carcinoma was established by subcutaneous implantation of cultured Eca-109 cell lines into nude mice. The mice were randomly divided into 3 groups, namely control group （ saline plus empty seed） , 1251 seed group （22.2 MBq x 1 seed） , and DDP group （cisplatin at the dose of 1 mg/kg） , to receive corresponding treatment. The growth rate and the pathological changes of esophageal carcinoma were observed. Results The animals were sacrificed 16 days after irradiation. The average tumor weight in control group, ^125I seed group, and DDP group were （ 0. 20 ± 0. 06） g, （ 0. 12 ± 0. 03 ） g and （ 0. 12 ± 0. 05 ） g, respectively （ P 〈 0. 05 ）. Pathological findings included degeneration and necrosis of the tumor cells. Compared to the control group, the necrosis areas in ^125I seed group and DDP group were significantly larger than those in control （P 〈 0. 05 ）. Conclusion ^125I seed brachytherapy in esophageal carcinoma could cause degeneration and necrosis of the tumor cells and had inhibitory effect on tumor growth.

关 键 词：^125I粒子 近距离放射疗法 食管肿瘤 肿瘤移植 

分 类 号：R735[医药卫生—肿瘤]