双环醇片预防肿瘤化疗药物性肝损害的研究  

Effectiveness of bicyclol in preventing hepatic injury caused by chemotherapy

作　　者：崔成旭[1] 杜春霞[1] 张雯[1] 杨林[1] 周爱萍[1] 王金万[1] 

机构地区：[1]中国医学科学院 北京协和医学院 肿瘤医院内科,北京100021

出　　处：《癌症进展》2008年第6期555-557,共3页Oncology Progress

摘　　要：目的评价双环醇片对肿瘤化疗药物所致肝损害的预防作用。方法将26例肿瘤化疗药物性肝损害的病人,再次按照原方案化疗时每日加用双环醇片75mg保肝治疗,形成自身对照。观察两种治疗方式病人肝功能的变化。结果单纯化疗组与化疗加用双环醇片出现肝功能Ⅰ～Ⅳ度损害的发病率分别为73.1%和29.4%,有显著性差异(P<0.01),肝损害程度分布上的差异亦有显著性(P<0.01),表明化疗加用双环醇片组的肝功能损害发病率较低且肝损害程度较轻。结论本研究表明抗肿瘤化疗同时加用双环醇片75mg/d保肝治疗可预防化疗药物对肝脏的损害。Objective To evaluate the effectiveness of bicyclol in preventing hepatic injury caused by chemotherapy durgs. Methods The study used an auto-control method. Totally 26 patients with hepatic injury caused by chemotherapy durgs orally received bicyclol 75mg/d when they started another chemotherapy cycle. The change of liver function were observed. Results The incidence of I - IV degree hepatic injuries was 29. 4% in the group of chemotherapy thicycld, and was 73. 1% in the chemotherapy group without using bicyclol （P 〈0. 01 ）. The distribution of hepatic injury degree also differed between two groups （ P 〈 0. 01 ）. Conclusion Bicyclol 75 mg tablets daily is effective in preventing hepatic injury caused by chemotherapy.

关 键 词：双环醇 化疗 肝损害 预防 

分 类 号：R730.53[医药卫生—肿瘤] R730.6[医药卫生—临床医学]