膀胱癌患者手术治疗前后尿液NMP22 UBC BTA CA-199和β_2-MG水平变化分析  

Analysis of the Level of NMP22,UBC,BTA,CA-199 andβ_2-MG in Urine Before and After Surgery in Patient with Bladder Cancer

作　　者：李扬 林章礼 郑衍平[1] 许瑞明 张敬成[3] 卢小卓[4] 

机构地区：[1]广东省汕头市中医医院,广东汕头515031 [2]广东省汕头市第二人民医院,广东汕头515031 [3]汕头大学医学院第一附属医院,广东汕头515041 [4]暨南大学第四附属医院,广东广州510220

出　　处：《河北医学》2008年第12期1400-1403,共4页Hebei Medicine

基　　金：广东省医学科研基金专项课题[A2006648]

摘　　要：目的:评价监测手术前后尿中NMP22、UBC、BTA、CA-199和β2-MG含量对膀胱癌患者预后判断和监测早期复发的临床意义。方法:应用酶联免疫吸附试验(ELISA)检测膀胱癌疑似尿中NMP22、UBC、BTA的浓度,采用化学发光法检测CA-199和β2-MG浓度。结果:膀胱癌患者手术治疗后,尿NMP22、UBC、BTA、CA-199与手术前比较显著降低(P<0.05),但均显著高于正常组(P<0.05);而β2-MG手术前后无显著变化,均显著高于正常组(P<0.05);对于晚期膀胱癌,尿NMP22、UBC、CA-199与手术前比较显著降低(P<0.05),但均显著高于正常组(P<0.05);而BTA、β2-MG手术前后无显著变化,均显著高于正常组(P<0.05)。结论:尿液中NMP22、UBC、BTA、CA-199水平可作为监测膀胱癌的标志物,用于评价手术预后和监测早期复发;而对于晚期膀胱癌,应除外BTA。Objective： To evaluate the clinical value of NMP22, UBC, BTA, CA - 199 and β2 -- MG in urine in the prognosis judgement and early recrudescent. Method： The concentration of NMP22, UBC and BTA were determined by ELISA, the concentration of CA - 199 and β2 - MG were determined by chemiluminescence method. Result： The concentration of NMP22, UBC and CA - 199 in urine after surgery were significantly lower than that before surgery in patients with bladder cancer of late stage （ P 〈 0.05 ）, but were significantly higher than the normal control group. β2 - MG didn＇ t differ between before and after surgery, but were significantly higher than the normal control group. Conclusion： The level of NMP22 , UBC, BTA and CA - 199 in urine after surgery were significantly lower than before surgery, and thus could be used to evaluate the prognosis.

关 键 词：核基质蛋白22 尿膀胱癌抗原 膀胱肿瘤抗原 糖类抗原199 β2微球蛋白 膀胱癌 

分 类 号：R737.14[医药卫生—肿瘤] R587.2[医药卫生—临床医学]