^18F-氟脱氧葡萄糖PET-CT在非小细胞肺癌临床分期及经治患者疗效评价中的应用  

The application of ^18F-fluorodeoxyglucose PET-CT in staging and curative effect evaluation of accepted therapy cases of non-small cell lung cancer

作　　者：曹霞[1] 谢爱民[2] 莫逸[2] 彭翔[2] 

机构地区：[1]湖南省肿瘤医院放疗科,长沙410013 [2]湖南肿瘤医院PET-CT中心,长沙410013

出　　处：《国际放射医学核医学杂志》2008年第4期213-216,共4页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：目的评价^18F-氟脱氧葡萄糖（^18F-FDG）PET—CT在非小细胞肺癌临床分期和经治患者中的应用价值。方法（1）比较32例初诊患者CT与PET—CT在临床分期上的差别。（2）观察肿瘤大小与最大标准化摄取值（SUVmax）相关性。（3）比较30例经治患者CT、PET-CT发现残留、新发病灶数的差异。结果（1）PET-CT上调及下调分期各7例，分期改变率43．8％（14／32）。PET-CT改变NM分期例数的差别无统计学意义。（2）SUVmax与肿瘤大小呈正相关（L=0．426，P〈0．05）。（3）PET-CT较CT多发现残留病灶3个（Z=-0．520，P〉0．05），新发病灶数19个（Z=-2．871，P〈0．05）。结论^18F-FDG PET-CT对确定非小细胞肺癌临床分期具有优势；有助于对经治患者新发病灶的检出。Objective To assess the use value of ^18F-FDG PET-CT in non-small cell lung cancer. Metheds （1） The CT and PET-CT image of 32 cases non-small cell lung cancer cases were compared in staging. （2）The relativety between tumor size and SUVmax was observed. （3） Thirty cases with accepted therapy were compared to find the differences of remains and new outbreak lesions. Results （1） Seven cases were upstaged and 7 cases were downstaged. Changing rate in staging by PET-CT was 43.8% （14/32） . The difference of altered stage lymph node and metastasis in number was not in statistical significance by ^18F- FDG PET-CT. （2） Spearman grade correlation coefficient rs was 0.426. There were positive correlation between SUVmax and the tumor size （P〈0.05）. （3） PET-CT found 3 more remain lesions（Z=-0.520, P〉0.05） and 19 more new outbreak lesion （Z=-2.871, P〈0.05） than that of CT. Conclusion ^18F-FDG PET-CT had superiority in determining staging of non-small cell lung cancer, and was conducive in cheaking new outbreak lesions of accepted therapy cases.

关 键 词：癌 非小细胞肺 氟脱氧葡萄糖F18 体层摄影术 发射型计算机 体层摄影术  X线计算机 肿瘤分期 

分 类 号：R730.44[医药卫生—肿瘤]