基因治疗联合放射治疗恶性肿瘤  

Gene therapy and radiotherapy in malignant tumor

作　　者：张耀文[1] 曹永珍[1] 李进[2] 王芹[2] 

机构地区：[1]天津医科大学总医院放疗科,300052 [2]中国医学科学院放射医学研究所分子核医学重点实验室,天津300192

出　　处：《国际放射医学核医学杂志》2008年第4期247-250,共4页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金资助项目（30770638）;2.天津市自然科学基金资助项目（05YFJMJC12100）

摘　　要：肿瘤治疗是目前医学研究的重点之一，基因治疗与放射治疗方法的结合倍受重视，根据技术特点这种联合治疗方法主要有：免疫基因治疗联合放疗、直接杀伤或抑制肿瘤细胞的基因治疗联合放疗、抗肿瘤血管生成的基因治疗联合放疗以及辐射保护性基因治疗。综述了近年来基因治疗联合放射治疗恶性肿瘤的研究现状以及可能的作用机制。Tumor treatment is one of the most important fields in medical research. Nowadays, a novel method which is combined gene therapy with radiotherapy plays an important role in the field of cancer research, and mainly includes immune gene therapy combined with radiotherapy, suicide gene therapy or tumor suppressor gene therapy combined with radiotherapy, antiangiogenesis gene therapy combined with radiotherapy and protective gene therapy combined with radiotherapy based on the technical features. This review summarized the current status of combined therapies of gene therapy and radiotherapy and possible mechanism.

关 键 词：肿瘤 基因疗法 放射疗法 

分 类 号：R730[医药卫生—肿瘤]