中药复智散对阿尔茨海默病患者局部脑血流灌注的影响  

Effects of Chinese Compound Fuzhisan on Regional Perfuse Index in Patients with Alzheimer Disease

作　　者：刚宝芝[1] 杨宝峰[2] 王德生[1] 杨志杰[3] 马铎[3] 

机构地区：[1]哈尔滨医科大学第一临床医学院神经内科,黑龙江哈尔滨150001 [2]哈尔滨医科大学,黑龙江哈尔滨150001 [3]哈尔滨医科大学第一临床医学院核医学科,黑龙江哈尔滨150001

出　　处：《中国神经免疫学和神经病学杂志》2008年第6期420-422,474,共4页Chinese Journal of Neuroimmunology and Neurology

基　　金：国家自然科学基金资助项目(30670726);黑龙江省自然科学基金重点资助项目(ZJY03-5);黑龙江省青年科学技术专项基金资助项目(QCO5C86);哈尔滨医科大学第一临床医学院院内基金资助项目;黑龙江省卫生厅资助项目(2007-217)

摘　　要：目的用单光子发射计算机断层扫描(SPECT)评价复智散对阿尔茨海默病(AD)患者局部脑血流灌注影响。方法对AD患者24例(AD组)、健康对照者12名(NC组)进行神经量表测定,AD组复智散治疗前和规范治疗40d后行SPECT评价局部脑血流和MMSE、ADAS-noncog神经量表测定。结果复智散能改善AD患者所观察脑区的脑血流灌注(P<0.05),以顶叶、额叶和扣带回区尤为明显(P<0.01),并能改善记忆力、语言、定向力及行为和情感等临床症状(P<0.01)。结论复智散可通过提高AD患者局部脑血流灌注而改善其认知和非认知功能。Objective To investigate effects of Chinese compound Fuzhisan on regional cerebral blood flow in patients with Alzheimer disease （AD） by SPECT. Methods Twenty-four elderly AD patients （AD group） completed 40 d treatment with Fuzhisan. 12 normally aging adults were enrolled as control group. Regional cerebral flow was investigated by SPECT. MMSE,ADAS-noncog tests were performed. After 40 d treatment, brain imaging and neuropsychological tests were conducted again. Results SPECT imaging evaluation showed significant increase of cerebal blood flow in all investigated regions of brain after 40 d treatment with Fuzhisan, especially in parietal, frontal and cingulated regions. Statistical analysis revealed the improving effects of Fuzhisan on memory, language, orientation, emotional and behavioral function. Conclusions The effect of Fuzhisan on MMSE and ADAS-noncog might be due to increasing the regional cerebral blood flow.

关 键 词：中药复智散 阿尔茨海默病患者 局部脑血流灌注 单光子发射计算机断层扫描 

分 类 号：R749.16[医药卫生—神经病学与精神病学]