E-cad-β-cat复合体表达及临床病理特征与食管癌预后的关系  

E-cadherin-β-catenint complex expression and clinicopathologic properties in esophageal carcinoma patients and their relationship with the prognosis

作　　者：林香春[1] 吴静[1] 王沧海[1] 魏南[1] 寇炜[2] 姬瑞[3] 路红[3] 

机构地区：[1]北京大学第九临床医院北京世纪坛医院消化科,北京市100038 [2]西北民族大学医学院,甘肃省兰州市730000 [3]兰州大学第一医院消化科,甘肃省兰州市730000

出　　处：《世界华人消化杂志》2008年第32期3687-3691,共5页World Chinese Journal of Digestology

摘　　要：目的:探讨食管癌患者E-钙粘蛋白(E-cadherin,E-cad)和β-连环素(β-catenint,β-cat)复合体表达及临床病理特征与食管癌患者术后生存的关系.方法:收集1998-2001年本院行食管癌根治术后的标本67例,应用免疫组织化学S-P法进行E-cad和β-cat复合体测定,结合病理学特征与患者生存期进行Kaplan-Meier单因素分析和Cox回归多因素模型分析.结果:食管癌患者的年龄、肿瘤的分化程度、浸润深度、淋巴结转移以及E-cad和β-cat表达是影响患者预后的重要因素;浸润深度、病理分级和淋巴结转移可作为独立的预后预测因子(P=0.039,0.006,0.020),风险度分别为2.675,3.077,2.958.而E-cad和β-cat不可作为独立的因子.结论:食管癌患者E-cad和β-cat复合体异常表达和食管癌的临床病理特征是影响患者预后的重要因素,且后者是独立的预后预测因素,其中分化程度最为重要.AIM： To investigate the expression of E-cadherin （E-cad） and β-catenint （β-cat） complex in esophageal carcinoma （EC） tissue and the clinicopathologic properties in EC patients and to further explore their relationship with the prognosis. METHODS： The data of 67 EC patients undergoing radical esophagectomy from 1998 to 2001 were reviewed and analyzed. The expression of E-cad and β-cat in the resected esophageal carcinoma tissue was detected using immunohistochemical technique. The prognostic factors were analyzed by Kaplan-Meier univariate and Cox multivariate survival analyses. RESULTS： The univariate Kaplan-Meier analysis showed that age, the degree of tumor differentiation, depth of invasion, lymph node metastasis and the expression of E-cad and β-cat complex were very important prognostic factors for EC patients. The multivariate analysis demonstrated that the degree of tumor differentiation and depth of invasion, lymph node metastasis were independent prognostic factors （P = 0.039, 0.006, 0.020）, Risk degree were 2.675, 3.077, 2.958 while E-cad-β-cat could not be used as independent prognostic factors for EC patients. CONCLUSION： Both the expression of E-cad - β-cat complex and clinicopathologic properties are very important for prognosis of EC patients. The clinicopathologic properties could be used as independent markers for predicting the prognosis. The degree of tumor differentiation is the most important prognostic factor.

关 键 词：E-钙粘蛋白 Β-连环素 食管癌 预后 

分 类 号：R735.1[医药卫生—肿瘤]