胆碱酯酶抑制剂对重症肌无力电生理学检查结果的影响  

The effects of cholinesterase inhibitors on electrophysiological tests in patients with myasthenia gravis.

作　　者：刘银红[1] 许贤豪[1] 崔丽英[2] 秦绍森[1] 王湘[1] 

机构地区：[1]卫生部北京医院神经内科,北京100730 [2]中国医学科学院中国协和医科大学北京协和医院神经内科

出　　处：《中国神经精神疾病杂志》2008年第11期654-657,共4页Chinese Journal of Nervous and Mental Diseases

摘　　要：目的探讨胆碱酯酶抑制剂对重症肌无力(myasthenis gravis,MG)电生理学检查结果有无影响。方法对53例MG肌注新斯的明1.5 mg,每例均在注射前后依次进行临床绝对评分、右侧伸指总肌的单纤维肌电图(single fiber electromyography,SFEMG)和左侧桡神经低频重复电刺激(repetitive nerve stimulation,RNS)检查,比较用药前后各项指标的变化。结果发现用药前后SFEMG中平均颤抖(jitter)、异常电位对和阻滞电位对的比例均无统计学差异(P>0.05);与此同时用药后RNS波幅递减的幅度和临床绝对评分均较用药前显著降低(P均为0.000)。结论胆碱酯酶抑制剂对MG的SFEMG的各项指标均无明显影响,而能显著改善RNS结果和临床症状的评分。Objective To investigate the effects of cholinesterase inhibitors on electrophysiological parameters in patients with myasthenis gravis（MG）. Methods Single fiber electromyography （SFEMG） on the right extensor digitorum communis and low frequency repetitive nerve stimulation（RNS） on the left radial nerve were performed in 53 MG patients before and after intramuscular injection of 1.5 mg neostigmine, all the parameters before and after the injection were recorded. Results There was no significant difference in mean jitter,the percentage of abnormal and blocking potential pairs（ P value is 0. 092,0. 817 and 0. 384 respectively） whereas there was a significant decrease in the percentage decrement of RNS and clinical absolute scores（ both P values were 0. 000）between before and after the injection. Conclusions The findings demonstrated that chofinesterase inhibitors doesn＇t affect and instead significantly improve accuracy and reliability of RNS and clinical scores.

关 键 词：重症肌无力 胆碱酯酶抑制剂 单纤维肌电图 重复电刺激 临床评分 

分 类 号：R746.1[医药卫生—神经病学与精神病学]