上皮性卵巢癌组织中组织激肽释放酶15的表达  

Expression of human kallikrein 15 in the epithelial ovarian carcinoma tissue

作　　者：王巍[1,2] 史惠蓉[1] 纪妹[1] 卫玲[1] 

机构地区：[1]郑州大学第一附属医院妇产科,郑州450052 [2]晋城市人民医院妇产科,晋城048000

出　　处：《郑州大学学报（医学版）》2008年第6期1177-1179,共3页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:研究上皮性卵巢癌组织中人类组织激肽释放酶15(KLK15)蛋白的表达。方法:应用免疫组化SP法,检测60例上皮性卵巢癌组织、20例上皮性良性卵巢肿瘤组织、10例正常卵巢组织中KLK15蛋白的表达情况。结果:卵巢癌组织中KLK15的表达阳性率(45/60,75%)高于正常(1/10,10%)及良性卵巢组织(8/20,40%)(P<0.01),在后2者中的表达阳性率差异无统计学意义(P>0.05)。KLK15表达阳性率随卵巢癌细胞分化程度降低而增高(P<0.05),随临床分期增加而增高(P<0.05);伴有区域淋巴结转移者,其表达阳性率增高(P<0.05)。KLK15阴性表达者生存时间较KLK15阳性者延长(P<0.05),KLK15表达与卵巢癌患者生存时间相关(χ2=5.96,P=0.014 6)。结论:KLK15表达与上皮性卵巢癌的进展密切相关,可作为判断卵巢癌恶性程度及评估不良预后的重要指标。Aim： To investigate the expression of human kallikrein 15（KLK15） in the primary epithelial ovarian carcinoma and the clinical significance.Methods：Expression of KLK15 proteins in 60 cases of malignant ovarian epithelial tumors 20 cases of benign adenoma and 10 cases of normal orarian tissue were evaluated by immunohistochemical staining.Results： Expression of KLK15 protein in malignant primary ovarian epithelial tumors tissue was 75%（45/60）,significantly higher than 40%（8/20） in ovarian benign adenoma and 10%（1/10） in normal tissues（P〈0.05）.There was no statistical significance in the expression rate between benign tissue and normal ovarian tissue（P〉0.05）.Expression of KLK15 protein was higher in the poorly differentiated tumor tissue and in the advanced patients（P〈0.01）,and also in the tumor tissues from the patients with local lymphnode metastases（P〈0.01）.The KLK15 expression was positirely correlated with overall survival of patients（χ^2=5.96,P=0.014 6）.Conclusion： The overexpression of KLK15 may serve as a useful marker for assessment of the biological behavior of epithelial ovarian cancer and for assessing the malignancy prognosis.

关 键 词：卵巢肿瘤 组织激肽释放酶15 预后 

分 类 号：R737.31[医药卫生—肿瘤]