原发性血色病患者放血疗法疗效观察  

Observation of curative effect of blood-letting therapy in patients with primary hemochromatosis

作　　者：徐朴[1] 周佑德[1] 李艳[1] 

机构地区：[1]武汉大学人民医院检验科血库,武汉430060

出　　处：《临床血液学杂志（输血与检验）》2008年第6期640-641,共2页Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)

摘　　要：目的:观察用放血疗法治疗原发性血色病的治疗效果。方法:对确诊的11例原发性血色病患者进行放血治疗,并在放血治疗前后检测患者的丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、血糖(BS)、血清铁(Fe)、血清铁蛋白(FER)水平,同时检测14例对照者的上述指标。结果:治疗前的ALT、AST和治疗前后的Fe、FER明显高于对照组,差异有统计学意义(P<0.01);治疗后的ALT、AST、Fe和FER明显低于治疗前水平,差异有统计学意义(P<0.01)。结论:放血疗法可显著降低原发性血色病患者体内的含铁量,改善患者的肝功能。Objective： To observe the curative effect of blood-letting therapy in primary hemochromatosis. Method： 11 patients with primary hemochromatosis were treated with blood-letting therapy, and the levels of alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, blood sugar（BS）, serum iron（Fe） and serum ferritin（FgR） before and after treatment in patients and in controls were measured. Result：The levels of ALT and AST before treatment , Fe and FER before and after treatment in patients were significantly higher than those of control group（P〈0.01）, the levels of ALT, AST, Fe and FER after treatment were significantly lower than those before treatment（P〈0.01）. Conclusion：The iron content in patients with primary hemochromatosis may be decreased significantly by blood-letting therapy, and the liver function may be obviously ameliorated at the same time.

关 键 词：血色病 放血疗法 血清铁 铁蛋白 

分 类 号：R457.1[医药卫生—治疗学] R589.9[医药卫生—临床医学]