化疗栓塞对肝细胞癌MMP-2、TIMP-2表达的影响  

The effect of chemoembolization on MMP-2 and TIMP-2 expressions of hepatocellular carcinoma

作　　者：肖运平[1,2] 肖恩华[2] 罗建光[2] 尚全良[2] 梁斌[2] 吴海军[2] 李默秋[3] 

机构地区：[1]柳州广西医科大学第五附属医院柳州市人民医院放射科,545001 [2]中南大学湘雅二医院放射科 [3]中南大学湘雅二医院病理科

出　　处：《介入放射学杂志》2008年第11期784-786,共3页Journal of Interventional Radiology

基　　金：国家自然科学基金项目(30070235,30470508);湖南省自然科学基金(06JJ20081);湖南省科技厅基金项目(04-SK-306-2)

摘　　要：目的探讨MMP-2、TIMP-2在肝细胞癌(HCC)中表达的意义及化疗栓塞对其表达的影响。方法47例经手术病理证实的原发性肝细胞癌,其中25例单纯手术切除,22例经导管动脉化疗栓塞(TACE)后行Ⅱ期切除,用免疫组化方法检测两组标本MMP-2、TIMP-2蛋白表达。结果有、无转移或完整包膜的肝细胞癌MMP-2表达差异有统计学意义(χ2=6.518、6.038,P<0.05);与单纯手术组相比,TACE组肝细胞癌MMP-2表达明显降低(χ2=4.854,P<0.05)、TIMP-2表达明显增高(χ2=5.144,P<0.05);MMP-2与TIMP-2表达存在显著负相关(r=-0.392,P<0.05)。结论MMP-2、TIMP-2与HCC的侵袭转移潜能相关,化疗栓塞有助于抑制HCC侵袭与转移潜能。Objective To study the significance and the effect of transeatheter arterial chemoembolization（TACE） on MMP-2 and TIMP-2 expressions. Methods Forty-seven pathologically verified HCC patients included surgical resection alone 25 cases and second stage surgical resection after chemoembolization 22 cases. Immunohistochemical staining for MMP-2 and TIMP-2 expression were performed in all specimens. Results There was significant difference in MMP-2 expressions between patients with or without metastasis（X^2 = 6.518,P 〈 0.05） and complete capsule （X^2 = 6.038 ,P 〈 0.05）. MMP-2 expression was even lower and TIMP-2 expression was even higher in TACE group than surgical resection group （P 〈 0.05） ; a significant negative correlation was observed between the expressions of MMP-2 and TIMP-2（r = -0.392, P 〈 0.05）. Conclusion HCC metastatic potentiality is correlative with MMP-2 and TIMP-2 expressions and chemoembolization is helpful for restraining the invasive and metastatic potentialities of HCC.

关 键 词：肝肿瘤 化疗栓塞 治疗性 基质金属蛋白酶 基质金属蛋白酶组织抑制剂 

分 类 号：R735.7[医药卫生—肿瘤]