卵巢上皮性癌组织黄体生成激素-绒毛膜促性腺激素受体蛋白的表达  

LHCG Receptor Protein Expression in Epithelial Ovarian Cancer

作　　者：崔金全[1,2] 郭燕燕[1,2] 尤宗兵[1,2] 温宏武 曹泽毅[1,2] 

机构地区：[1]北京医科大学第一医院妇产科 [2]河南医科大学附属第二医院妇产科

出　　处：《中华妇产科杂志》1997年第12期742-745,I046,共5页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的：探讨卵巢上皮性癌组织黄体生成激素（ＬＨ）与人绒毛膜促性腺激素（ｈＣＧ）受体（ＬＨ－ＣＧ）表达与临床预后的关系。方法：应用Ｗｅｓｔｅｒｎ免疫印迹方法，对４０例卵巢上皮性癌组织ＬＨ－ＣＧ受体蛋白进行半定量分析；应用免疫组化方法检测受体蛋白表达的部位。结果：４０例中，ＬＨ－ＣＧ受体蛋白阳性表达率为７２．５％（２９／４０），其中Ⅰ、Ⅱ期患者高于Ⅲ、Ⅳ期患者，但差异无显著性（Ｐ＞０．０５）。高分化癌的受体含量约为低分化癌的２倍，两组比较，差异有显著性（Ｐ＜０．０５）。ＬＨ－ＣＧ受体蛋白高表达患者的１年和３年生存率分别为８３．９４％和６７．１５％，低表达患者１年和３年生存率均为３３．４３％，两者比较，差异有显著性（Ｐ＜０．０５）。结论：卵巢上皮性癌ＬＨ受体高表达者，预后较低表达者好。Objective: To evaluate the relationship between (LHCG) receptor expression and prognosis in epithelial ovarian cancer. Methods: The ralative quantity of LHCG receptor protein of epithelial ovarian cancer tissuse was detected with semiquantitative western immunobloting in 40 cases. The LHCG receptor protein was located with immunohistochemistry. The LHCG receptor was termed high expression if its concentration was more than and/or equal to the median, and low expression if its concentration was less than the median. 36 of the 40 cases were followed up at various intervals, the longest follow up period was 56 months. There were 16 cases with high LHCG expression and 20 cases with low LHCG receptor expression in which 9 cases died. Results : The positive rate of LHCG receptor protien expression was 72.5% (29/40). The level of LHCG receptor protein expression in patients with stages Ⅰ and Ⅱ was higher than that in patients with stages Ⅲ and Ⅳ, but it is not significant (P>0.05). The LHCG receptor concentration in the welldifferentiated cancer group was twice as much as that in the poorlydifferentiated cancer group. The difference between the welldifferentiated group and the poorlydifferentiated group was significant (P<005). The 1year and 3year survival rates were 83.94% and 67.15% respectively in the high LHCG receptor expression group. Both of the 1year and 3year survival rates were 33.34% in the low LHCG receptor expression group. The survival rates of the high expression group was significantly higher than those of the low expression group (P<0.05). LHCG receptor expression did not correlate with age, lymph node metastases, the size of residual tumor and CA125. Conclusion: The prognosis of patients with high LHCG receptor expression is better than that of those with low expression.

关 键 词：卵巢肿瘤 受体 LH 上皮性癌 HCG 

分 类 号：R737.310.2[医药卫生—肿瘤]