Ni_3Al/HAP生物复合材料的制备及其生物相容性  

Preparation and biocompatibility of Ni_3Al/HAP composite bio-ceramics

作　　者：孙昌[1,2,3] 孙康宁[1,2] 刘晓飞[1,2] 

机构地区：[1]山东大学材料的液态结构及其遗传性教育部重点实验室,济南260061 [2]山东大学工程陶瓷省重点实验室,济南250061 [3]山东省产品质量监督检验研究院,济南250100

出　　处：《材料科学与工艺》2008年第5期614-615,共2页Materials Science and Technology

基　　金：国家自然科学基金资助项目(30170269);国家高技术研究发展计划项目(2003AA302232)

摘　　要：为了制备N i3A l/HAP生物复合材料并评价其生物相容性,将N i3A l/HAP生物复合材料置入大白鼠臀部的肌肉中,在置入材料的第1、3、7 d等不同的时间段取出试样周围的组织进行组织学观察.结果显示,所有动物术后活动正常,进食好,毛色光亮;伤口Ⅰ期愈合,无切口感染,表皮无明显变化;光学显微镜下观察,肌肉组织细胞正常,早期为炎症反应,并逐渐减轻和消失.N i3A l/HAP生物复合材料有较好的生物相容性.To prepare Ni3Al/HAP biocomposites and evaluate the bioeompatibility of Ni3Al/HAP composite, the biocomposites were implanted into the hip muscle of big white mice. The muscle around the bio-ceramics was observed with histological methods after being treated for 1,3 and 7 days respectively. Results indicate that the mice in the experiment act normally and their wounds are healed at I Stage. The histological observation shows that the foreign body reaction can be observed at the early stage of the implantation. Inflammatory cells decrease by time and disappeared gradually. It can be concluded that the prepared composite bio-ceramies has good biocompatibility.

关 键 词：生物复合材料 Ni3Al/HAP 生物相容性 

分 类 号：R318.08[医药卫生—生物医学工程]