Ⅰ型胶原在去下牙槽神经支配下颌骨骨折愈合中的表达  

The expression of collagen Ⅰ during mandibular fracture healing with the inferior alveolar nerve mutilated

作　　者：张伟[1] 刘麒麟[1] 于子莹[1] 王为民[2] 孙宾[1] 

机构地区：[1]吉林大学口腔医院口腔颌面外科,吉林长春130041 [2]吉林油田总医院口腔科,吉林松原138006

出　　处：《华西口腔医学杂志》2008年第5期486-489,共4页West China Journal of Stomatology

基　　金：江西省卫生厅重点科研基金资助项目(200214)

摘　　要：目的建立稳定性下牙槽神经损伤骨折模型,探讨下牙槽神经对下颌骨骨折骨痂中Ⅰ型胶原表达的影响。方法选用大耳白兔,游离双侧下牙槽神经,右侧保留,左侧切断,在此基础上制作2mm×5mm的骨折模型,应用苏木精-伊红、变色酸2R-亮绿染色、原位杂交染色检测下颌骨骨折愈合情况及愈合过程中Ⅰ型胶原的表达情况。结果正常下牙槽神经支配的下颌骨顺利完成骨折愈合,神经离断后骨折愈合延迟。Ⅰ型胶原原位杂交染色表明在第1、2周保留神经侧较神经离断侧Ⅰ型胶原mRNA明显,差异有统计学意义(P<0.05);在第3、4周,两侧之间差异无统计学意义(P>0.05)。结论下牙槽神经对下颌骨愈合有调节作用,可影响Ⅰ型胶原mRNA的早期表达。Objective To compare the regional load deflection rate （LDR） of multiloop edgewise arch wire （MEAW） of three dimensions with coupled use of two dimension brackets in the individual interbracket span, to understand the mechanical properties of MEAW. Methods The MEAW arch wires of stainless steel of three dimensions, 0.41 mm×0.56 mm, 0.43 mm×0.64 mm and 0.46 mm×0.64 mm, were bent into single L-loop. The study was performed with the coupled use of 0.41 mm×0.56 mm wires with 0.46 mm×0.64 mm bracket （A bracket） and 0.43 mm× 0.64 mm, 0.46 mm×0.64 nun wires with 0.56 mm×0.71 mm bracket （B bracket）. The LDR of each L-loop at the individual interbracket span when loading and unloading was measured. The data were analysed by SPSS 11.0. Results Compared the regional LDR for the couple of 0.41 mm×0.56 mm L-loop with A bracket with those for the couple of 0.43 mm×0.64 mm L-loop with B bracket, the former showed lower value than the latter at regions between the upper central and lateral incisor, the lower central and lateral incisor, and between the lower lateral incisor and canine （P〈0.05）. For the rest regions, the two couples exhibited similar value to the regional LDR （P〉0.05）. The regional LDR for the couple of 0.41 mm×0.56 mm L-loop with A bracket were lower at all regions than those for the couple of 0.46 mm×0.64 mm L-loop with B bracket （P〈0.05） except that at the region between the lower first and second molars which showed similar value between the two couples. Conclusion The coupled use of B bracket with 0.43 mm×0.64 mm MEAW arch wire and A bracketwith 0.41×0.56mm MEAW arch wire exhibited similar mechanical properties.

关 键 词：下牙槽神经 下颌骨骨折 Ⅰ型胶原 原位杂交 

分 类 号：R782.4[医药卫生—口腔医学]