EGFR及p21蛋白在肺癌中的表达  

Expression of EGFR and p21 protein in lung carcinoma

作　　者：王国凤[1] 曹敏[1] 陈培辉[1] 苏泳元[1] 孙丽萍[1] 

机构地区：[1]浙江医科大学附属第二医院病理科

出　　处：《临床与实验病理学杂志》1997年第4期311-313,I031,共4页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的：探讨表皮生长因子受体（ＥＧＦＲ）和ｐ２１蛋白表达与肺癌发生发展的关系及其两者的对应关系。方法：应用免疫组化Ｓ－Ｐ法对６３例肺癌及其癌旁组织进行了同位ＥＧＦＲ及ｐ２１蛋白的检测。结果：肺癌ＥＧＦＲ阳性率７７．７８％，其阳性率与病理类型及临床分期无关（Ｐ＞０．０５）。癌旁组织ＥＧＦＲ阳性率６７．９２％，其中增生组阳性率（７９．０６％）显著高于无增生组（３７．５０％）（Ｐ＜０．０１）。肺癌中ｐ２１蛋白的阳性率４７．６２％。腺癌阳性率显著高于鳞癌（Ｐ＜０．０５）。大细胞癌均阴性。ｐ２１蛋白表达与肺癌转移及临床分期无关。癌旁组织ｐ２１蛋白阳性率４５．７１％，增生组阳性率（６２．７９％）显著高于未增生组（１８．５１％）（Ｐ＜０．０１）。ＥＧＦＲ及ｐ２１蛋白在肺癌中的表达经χ２检验未显示一致性关系。结论：ＥＧＦＲ及ｐ２１蛋白过度表达和活性增强与癌旁上皮细胞增生有密切关系，并在肺癌发展过程中起作用，可能是肺癌发生的早期事件。ｐ２１蛋白及ＥＧＦＲ在肺癌中可能相互独立起作用。Purpose To investigate the expression of EGFR and p21 protein and their correlation and significance in genesis and progress of lung carcinoma. Methods Sixtythree cases of lung carcinoma and their paracarcinomous tissue were examined for EGFR and p21 protein using SP immunohistochemical method. Results The positivity rate of EGFR in lung cancer was 7778%, and was not concerned with pathological types and clinical stages of lung carcinoma. The positivity rate of EGFR in paracarcinomous tissue was 6792%. It was significantly higher in the hyperplastic tissue (7906%) than in the nonhyperplastic tissue (3750%) (P<001). The positivity rate of p21 protein in lung carcinoma was 4762%, and much higher in lung adenocarcinoma and bronchioalveolous cancer than in lung squamous cancer and small cell cancer (P<005). None of large cell cancer was positive. The expression of p21 protein was not associated with the metastasis and staging of the tumour. The positivity rate of p21 protein in paracarcinomous tissue was 4571%, and significantly higher in the hyperplastic (6279%) than in the nonhyperplastic (1851%) (P<001). There was not statistical compatibility between the expressions of EGFR and p21 protein through compatible examination. Conclusions The results suggest that overexpression and activity enforcing of EGFR and p21 protein are in close relationship with the hyperplasia of paracarcinomous epithelial cells and play an important role in progression of the lung cancer and may be the early event of the carcinogenesis. The action of EGFR and p21 protein in lung carcinogenesis is independent each other.

关 键 词：表皮生长因子 受体 肺肿瘤 P21基因 基因表达 

分 类 号：R734.2[医药卫生—肿瘤]