axin-2与牙发育的关系  

Advances in the research on axin-2 and tooth development

作　　者：徐秀敏[1] 梅陵宣[1] 

机构地区：[1]安徽医科大学附属口腔医院口腔内科,安徽合肥230032

出　　处：《国际口腔医学杂志》2008年第6期675-677,共3页International Journal of Stomatology

基　　金：安徽省科技攻关计划基金资助项目(07010300197)

摘　　要：axin是1997年发现的编码Axin蛋白的基因,该家族成员包括axin-1和axin-2。axin-2作为Wnt信号通路中的负调节因子,参与胚胎发育、细胞分化和器官形成等生理进程。牙发育过程同样受到严格的基因调控,基因的异常表达可能导致牙发育异常。有研究报道,axin-2可能与先天性缺牙有关,此外还与各类肿瘤发生密切相关,被认为是肿瘤抑制基因。下面就axin-2的结构、生物学特性、与牙发育关系等内容作一综述。Axin gene was been found since 1997 which encoded the Axin, the family include axin-1 and axin- 2 gene. Axin-2 gene is a negative regulator of Wnt/β-catenin signalling, regulates cellular proliferation, differentiation, and is essential for development and morphogenesis, tooth development is under strict genetic control, gcne affecting early tooth development. Axin-2 gene may be associated with familial tooth agenesis or oligodontia. It also acts as a tumor suppressor by limiting the deregulation of Wnt signalling that is common in some cancers. To study the axin-2 gene will be helpful for us to understand the aspects of tooth development.

关 键 词：少牙畸形 axin-2 牙发育 

分 类 号：R780.2[医药卫生—口腔医学]