The expression significance and associativity of ILK and PTEN in gastric cancer tissue  

胃癌组织中ILK、PTEN蛋白表达的意义(英文)

作　　者：Zhou Wang Xuechun Wang Jifeng Li Xichao Sun Xu Wang 

机构地区：[1]Department of Pathology, Jining Medical College, Jining 272013, China [2]Department of Neurology, Affiliated Hospital of lining Medical College, Jining 272029, China [3]Department of Pathology, Jining First People＇s Hospital, Jining 272013, China

出　　处：《The Chinese-German Journal of Clinical Oncology》2008年第12期701-703,共3页中德临床肿瘤学杂志（英文版）

基　　金：Supported by Sanitary Science and Technological Development Foundation of Shandong Province (2003HW015).

摘　　要：Objective: To research the contribution of ILK and PTEN to the carcinogenesis and development of gastric carcinoma and the relation with anti-oncogene PTEN. Methods: ILK and PTEN proteins, PTEN mRNA of 76 cases of normal gastric mucous and 112 cases of gastric carcinoma were detected by immunohistochemistry method and in situ hybridization. Results: The expression of ILK, PTEN protein in gastric carcinoma group and normal gastric mucosa group, muscular layer invasive group and no muscular layer invasive group, lymphatic metastasis group and non-lymphatic metastasis group were all statistical significance (P < 0.05 or P< 0.01). The expression of PTEN mRNA of gastric carcinoma group was lower than that of normal gastric mucosa group (P < 0.01). The expression of ILK and PTEN protein had negative correlation (r = -0.347, P < 0.01). Conclusion: ILK protein increasing and PTEN protein decreasing have closely relation with the genesis and development of gastric carcinoma, and controlling them may become a new treating target gastric cancer.

关 键 词：ILK PTEN gastric cancer 

分 类 号：R735.2[医药卫生—肿瘤]