肺癌患者血清VEGF与EGF的检测及其临床意义  

Detection of VEGF and EGF in Human Lung Carcinoma and Its Clinical Significances

作　　者：王洪刚[1] 刘锡范[1] 刘加法[1] 

机构地区：[1]潍坊市人民医院检验科,山东潍坊261041

出　　处：《医学综述》2008年第23期3662-3664,共3页Medical Recapitulate

摘　　要：目的研究血管内皮生长因子(VEGF)与表皮生长因子(EGF)在肺癌患者血清中的表达及不同病理类型中的表达差异。方法实验包括肺癌组34例,良性肺疾病组9例,健康对照组10例。用酶联免疫吸附法(ELISA)测定VEGF,放射免疫法(RIA)测定EGF。结果肺癌组血清VEGF与EGF的表达水平均高于良性肺疾病组和健康对照组,差异有统计学意义(P<0.05)。鳞癌,小细胞癌和腺癌患的血清VEGF、EGF表达水平差异均无统计学意义(P>0.05)。肺癌骨转移组血清VEGF表达水平明显高于无骨转移组,差异有统计学意义(P<0.05);而两组的EGF表达水平无统计学差异。结论肺癌患者血清VEGF与EGF高表达,可为肺癌的早期诊断及治疗提供参考依据。Objective To detect the serum levels of vascular endothelial growth factor （VEGF） and epidermal growth factor （EGF） in human carcinoma, and to analyze it＇s clinical features as well as pathophysiologieal characteristics. Methods The subjects in the study were divided into lung cancer group （ 34 patients） ,benign pulmonary diseases group （9 patients）, and health control group （10 patients）. VEGF and EGF was measured by enzyme-linked immunosorbent assay （ELISA） and radioimmunoassay （RIA） ,respectively. Results The serum levels of VEGF and EGF in lung cancer were higher than those in benign pulmonary diseases and health controls with signifieant difference （P 〈 0.05 ）. The serum levels of VEGF and EGF did not change between different histologic lung cancer. The serum levels of VEGF in the patients with osseous metastasis were significantly higher than those without. There were no signifieant differences in the serum levels of EGF between patients with osseous metastasis and those without osseous metastasis. Conclusion The serum levels of VEGF and EGF were high in lung cancer,which maybe helpful in diagnosis and therapy of early lung cancer.

关 键 词：肺癌 血管内发生长因子 表皮生长因子 

分 类 号：R734.2[医药卫生—肿瘤]