Cyclin D1及p16在非小细胞肺癌中的表达及其临床意义  

Expressions of Cyclin D1 and p16 in non-small-cell lung cancer and its clinical significance

作　　者：王立新[1] 洪永青[1] 高金瑜[1] 

机构地区：[1]江苏省淮安市第一人民医院呼吸科,223300

出　　处：《蚌埠医学院学报》2008年第6期754-756,共3页Journal of Bengbu Medical College

摘　　要：目的:研究细胞周期蛋白D1(Cyclin D1)及p16基因在人非小细胞肺癌组织中的表达和临床意义。方法:以免疫组化SP法检测62例非小细胞肺癌组织中及20例肺良性病变组织中CyclinD1及p16的表达。结果:CyclinD1及p16在肺癌组织中均有较高的表达,其阳性率分别为62.9%和56.5%;在肺良性病变中未发现CyclinD1的表达,p16阳性率为85.0%。CyclinD1的表达与肿瘤的大小、淋巴结转移及临床分期无关(P>0.05);p16的表达与肿瘤的大小无关(P>0.05),与淋巴结转移及临床分期有关(P<0.005)。结论:Cyclin D1的过表达与肺癌的发生有关,可作为肺癌早期诊断指标之一,而与肺癌发展和预后无关;p16异常与肺癌发生、发展及预后有关。Objective：To study the expressions of Cyclin D1 and p16 in the tissues of non-small-cell lung cancer（NSCLC）and its clinical significance.Methods：The expressions of Cyclin D1 and p16 in 62 cases of primary lung cancer were determined by immunohistochemical method and 20 cases of pulmonary benign cases acted as control.Results：The expressions of Cyclin D1 and p16 were high in the tissues of lung cancer,with a positive rate of 62.9% and 56.5%,respectively.The positive rates of Cyclin D1 and p16 in the 20 controls was 85.0%.The expression of Cyclin D1 was not related to the tumor＇s diameter,lymph node metastasis or clinical stages（P〉0.05）.The level of p16 was not related to the size of the tumor,but was associated with the lymph node metastases and clinical stages（P〈0.005）.Conclusions：Over expression of Cyclin D1 is related to the carcinogenesis and may act as a marker in the early diagnosis of lung cancer,but it has no correlation with the biological behavior or prognosis of lung cancer,while p16 is associated with the biological behavior and prognosis of lung cancer.

关 键 词：癌 非小细胞肺 肺肿瘤 细胞周期蛋白D1 P16 

分 类 号：R734.2[医药卫生—肿瘤]