塞克硝唑片治疗口腔厌氧菌感染的疗效观察  

Clinical investigation of secnidazole in treatment of oral anaerobic infection

作　　者：尹林[1] 桂冠[1] 许扬[1] 朱声荣[2] 丁俊清[3] 于浩[4] 梅亚宁[5] 

机构地区：[1]南京医科大学第一附属医院口腔科,南京210029 [2]华中科技大学同济医学院附属同济医院,武汉430030 [3]武汉大学人民医院,武汉430030 [4]南京医科大学统计教研室,南京210029 [5]南京医科大学第一附属医院检验中心,南京210029

出　　处：《口腔医学》2008年第11期596-598,共3页Stomatology

摘　　要：目的观察塞克硝唑片治疗口腔厌氧菌感染的有效性和安全性。方法采用多中心、随机、双盲、阳性药平行对照临床研究方法,将144例患者分成塞克硝唑片组(A组)和替硝唑片组(B组),各72例。分别在用药前后进行临床观察和细菌学检查。结果症状、体征评分2组间比较差异无显著性(P>0.05)。痊愈率:A组83.33%,B组82.86%,差异无显著性(P>0.05)。不良事件:A组4.17%,B组2.82%,差异无显著性(P>0.05),均无严重不良事件发生。细菌学检查:A组清除率100%,B组清除率95.45%,差异无显著性(P>0.05)。塞克硝唑最低抑菌浓度(MIC)值低于替硝唑。结论塞克硝唑片是治疗口腔厌氧菌感染安全有效的一种药物,抗菌活性优于替硝唑。Objective To study the efficacy and safety of secnidazole in treatment of oral anaerobic infection. Methods A muhicenter, randomized, double-blind, parallel positive drug controlled clinical study was conducted. 144 patients were equally divided into two groups, secnidazole-group （group A） and tinidazole tablets group （group B） with 72 cases in each. The clinical observation and bacteriology were observed before and after treatment. Results There was no significant difference （ P 〉 0. 05） in symptonrs and signs score between the two groups. The cure rate was 83.33 % in group A and 82.86% in group B, and the difference was not statistically significant （ P 〉 0. 05）. The rate of adverse events was 4.17% in group A and 2.82% in group B, and the difference was not statistically significant （ P 〉 0.05）. No serious adverse events occurred. The rate of killing anaerobic bacteria was 100% in group A and 95.45 % in group B, respectively. The difference was not statistically significant （ P 〉0. 05）. MIC of secnidazole was less than that of tinidazole. Conclusion Secnidazole is effective and safe in treatment of oral anaerobic infection, and antibacterial activity of secnidazole was better than that of tinidazole.

关 键 词：塞克硝唑 替硝唑 口腔厌氧菌感染 

分 类 号：R782.4[医药卫生—口腔医学]