眼眶肿瘤组织端粒酶活性表达及其临床意义  

Expression and clinical significance of telomerase activation in orbital tumor tissues

作　　者：岳岩[1,2] 魏锐利[1] 

机构地区：[1]第二军医大学附属长征医院眼科,上海市400003 [2]解放军总医院

出　　处：《眼科新进展》2008年第12期905-907,共3页Recent Advances in Ophthalmology

摘　　要：目的研究眼眶肿瘤组织中端粒酶活性的表达,为眼眶肿瘤的临床诊断开拓新思路。方法利用端粒重复序列扩增技术对83份眼眶恶性肿瘤组织、83份癌旁组织、165份眼眶良性肿瘤组织和6份正常眼眶组织端粒酶的活性进行检测。结果254例(337份)标本中,眼眶恶性肿瘤组织、癌旁组织、良性肿瘤组织的端粒酶活性阳性率分别为95.2(79/83)、3.6(3/83)、3.0(5/165);6份正常眼眶组织未检测到端粒酶活性的表达。眼眶恶性肿瘤组织与其他眼眶组织相比,端粒酶活性阳性率差异均有显著性统计学意义(P<0.0001)。结论眼眶病变组织端粒酶活性表达水平的检测对眼眶恶性肿瘤早期诊断具有应用价值。Objective To study the expression of telomerase activation for exploring new strategies on clinical diagnosis of orbital tumors tissues. Meth. ods Telomerase activation of malignant tumor tissues in 83 samples, adjacent non-tumor orbital tissues in 83 samples, benign tumor tissues in 169 samples and normal orbital tissues in 6 samples were detected with telomerase repeti- tive sequence amplification method. Results In 254 cases （337 samples）, the positive rates of telomerase activity in malignant tumor tissues, adjacent nontumor orbital tissues,benign tumor tissues were 95.2 % （ 79/83 ）, B. 6 % （ 3/83 ）, 3.0% （5/165 ）respectively,and not detected in 6 normal orbital tissues. The positive rate of telomerase activition in malignant tumor tissues groups was significantly higher than that of other groups（P〈0.000 1 ）. Conclusion The detection of telomerase activation is useful for diagnosis of orbital malignant tumor.

关 键 词：眼眶肿瘤 端粒酶 诊断 

分 类 号：R777.5[医药卫生—眼科]