糖皮质激素治疗视神经炎疗效评价及影响疗效因素分析  

Therapeutic evaluation of glucocorticoid on optic neuritis and analysis of effective factors

作　　者：张彩[1] 王大博[1] 白海青[1] 商卫卫[1] 房娇[1] 李廷[1] 

机构地区：[1]青岛大学医学院,山东省青岛市266003

出　　处：《眼科新进展》2008年第12期923-925,927,共4页Recent Advances in Ophthalmology

摘　　要：目的评价糖皮质激素治疗视神经炎(optic neuri-tis,ON)的效果,并分析影响本病疗效的相关因素。方法对1996年1月至2008年1月在我院收治的68例(116眼)ON患者的病案资料进行回顾性分析。结果糖皮质激素治疗ON的有效率为72.41,常规剂量地塞米松组与大剂量甲基强的松龙组的视力恢复速度及疗效比较,差异均无统计学意义(P>0.05);儿童患者的疗效最好,中青年次之,老年患者疗效最差(P<0.05);病程<15d患者的疗效好于病程≥15d的患者(P<0.05);不同入院视力视神经炎患者的疗效比较,差异无统计学意义(P>0.05);视盘炎患者的疗效好于视盘视网膜炎患者(P<0.05)。结论不同类型和剂量的糖皮质激素疗法不影响ON的视力恢复速度和治疗效果。随年龄及病程增长,本病疗效有变差趋势。不同临床类型可能对ON的疗效有一定影响。入院视力可能不影响本病的治疗效果。Objective To evaluate the therapeutic effect of glucocorticoid on optic neuritis（ON） and analyze the fhctors which may affect the therapeutic effect. Methods Retrospective analysis was taken on 68 patients（ 116 eyes） with ON in our hospital from January 1996 to January 2008. Results The effective power of glucocorticoid on treatment of ON was 72.41%. There was no statistical difference in visual recovery speed and therapeutic effect between group of normal dose dexamethasone and group of large dose methylprednisolone （ P 〉 0.05 ） ; The therapeutic effect on children was the best,, on youth and the middle-aged was better and on the old was the worst（ P 〈 0. 05）; The therapeutic effect on patients whose courses of disease were shorter than 15 days was better than that on patients with courses longer than 15 days （P 〈 0.05） ;There was no statistical difference in therapeutic effect on patients with different admission vision（ P〉0. 05 ） ;The therapeutic effect on patients with neuropapillitis was better than that with papilloretinitis（P 〈 0. 05 ）. Conclusion The types and doses of glucocorticoid have no impact on the visual recovery speed and therapeutic effect on the treatment of ON. The older the patients are, the worse the therapeutic effect becomes ;The longer the courses of disease are, the worse the therapeutic effect becomes; In the treatment of ON, the clinical types of optic neuritis may impact on the therapeutic effect to some extent and the admission vision may have no impact on the therapeutic effect.

关 键 词：视神经炎 药物疗法 糖皮质激素 地塞米松 甲基强的松龙 

分 类 号：R774.6[医药卫生—眼科]