登革病毒不同途径感染Balb/C小鼠的比较  

Comparison of dengue virus infection in BALB/c mice inoculated by different loutes

作　　者：李玉静[1] 赵卫[2] 张文炳[2] 张玲[2] 杨运高[1] 文小敏[1] 林培政[3] 

机构地区：[1]南方医科大学中医药学院 [2]南方医科大学公共卫生与热带医学学院病毒研究所,广州510515 [3]广州中医药大学,广州510405

出　　处：《广东医学》2008年第12期1948-1950,共3页Guangdong Medical Journal

基　　金：国家自然科学基金(编号:U0632009);广东省医学科学技术研究基金(编号:A2006382)

摘　　要：目的比较Balb/C小鼠不同途径接种登革病毒(DEN)产生的临床和病理学变化。方法分别以颅内注射、腹腔注射、皮下多点注射、混合注射等方式将登革2型病毒GZ14株接种到Balb/C小鼠体内,观察小鼠临床表现、体征、血清及内脏中病毒感染情况。结果各组小鼠均未出现典型的临床症状,但可以从体内分离出登革病毒。当感染方式不同时,血液检测结果及脏器损伤的情况也存在着一定的差异。结论不同的接种方式均可以使小鼠感染登革病毒,其中以混合注射的方式效果最佳。Objective To compare the clinical and pathologic changes of dengue virus （DEN2）infection in BALB/c mice inoculated by different routes. Methods BALB/c mice were inoculated with dengue virus （ DEN2 GZ14） by intracranial injection, intraperitoneal injection, subcutaneous multi -point injection or mixed injection. The clinical and pathologic changes were studied. Results All mice did not have classic clinical signs, but dengue virus was found from the body of mice. Detection of virus in the blood plasma, liver and brain were different with different inoculation routes. Conclusion Different inoculations result in DEN infection in mice, and mixed injection is better than other routes.

关 键 词：登革病毒 接种方式 BALB/C小鼠 

分 类 号：R57[医药卫生—消化系统] R373.33[医药卫生—内科学]