牙周病与冠心病相关性的Meta分析  

A Meta analysis on the correlation between periodontal disease and coronary heart disease

作　　者：耿娟[1] 胡国强[1] 叶方立[1] 邹毅刚[1] 

机构地区：[1]武汉科技大学医学院流行病和医学统计学教研室,湖北武汉430022

出　　处：《中国冶金工业医学杂志》2008年第6期637-639,共3页Chinese Medical Journal of Metallurgical industry

摘　　要：目的:探讨牙周病与冠心病的关联程度,为预防决策提供依据。方法:采用Meta分析法,对根据纳入标准和剔除标准筛选出的11篇关于牙周病与冠心病关系的研究资料(8篇病例对照研究、3篇队列研究)进行定量综合分析,计算有关危险因素的OR/RR值及95可信区间,并绘制森林图。结果:合并所有研究资料后进行异质性检验显示,χ2=6.87,P=0.74>0.05;采用固定效应模型进行Meta分析表明,有无牙周病对患冠心病的危险性相差显著,RR=1.45、95CI为1.36～1.54。结论:牙周病与冠心病呈明显相关性,且可能互为致病和加重病情的危险因素。应加强对牙周病的防治宣传,从而控制人群患冠心病的机率。Objective：To explore the correlation between periodontal disease（PD）and coronary heart disease（CHD）,and provide a firm basis of the strategic prevention. Methods：We conducted a systematic review of the published literatures about the relationship of PD and CHD. According to the inclusion criteria and exclusion criteria, 11 studies were selected （including 8 clinical controlled trails and 3 prospective cohort studies）. The data were analyzed by RevMan 4.2 software and SPSS13 software. Using the value of OR/RR and 95% CI as the assessmet of the the link between PD and CHD, then drawing the forest plot. Results： 11 original studies were enlisted and tested for heterogeneity X^2= 6.87, P= 0. 74, 〉0.05. Fixed effect model analysis shows that the summary RR was 1.45 （ 95% CI,1.36 to 1.90）,indicating a higher risk of future coronary heart disease in individuals with periodontal disease compared with those without. Conclusions：This result suggests that periodontal disease is significantly relates to coronary heart disease,they may be a risk indicator for each other. However,we should strengthen the prevention and cure of PD and control the probability of CHD.

关 键 词：牙周病 冠心病 META 分析 

分 类 号：R781.4[医药卫生—口腔医学] R541.4[医药卫生—临床医学]