氯诺昔康与中性及电荷型β-环糊精衍生物的包合作用  

Inclusion Behavior Between Lornoxicam and Neutral or Charged β-Cyclodextrins

作　　者：王茹林[1] 裴晓莉[1] 孙体健[1] 王浩江[1] 

机构地区：[1]山西医科大学化学教研室,山西太原030001

出　　处：《化学研究》2008年第4期70-72,共3页Chemical Research

基　　金：山西省科技厅自然科学基金资助项目(20051029)

摘　　要：采用溶解度法研究了不同pH值下氯诺昔康与中性及电荷型β-环糊精衍生物的包合作用.结果表明,氯诺昔康与3种环糊精都形成了1∶1的包合物.以包合常数作为包合作用的量度,在酸性和中性条件下包合能力较碱性强,其中磺丁醚-β-环糊精(SBE-β-CD)在酸性条件下包合常数最大.电荷型β-环糊精除了通常的疏水作用力为主客体间包合驱动力外,还存在额外的静电包合作用力.The inclusion interaction between lornoxicam and neutral or charged β-cyclodextrins （β- CDs） were studied by phase solubility method. The results showed that the 1 ： I inclusion compounds were formed beween lornoxicam and β-CDs. The inclusion capacity of β-CDs was strongger in acidic media and neutral media than in basic media, especially SBE-β-CD in acidic media. There were not only hydrophobic interaction but also electrostatic interaction beween ionic host and guest molecule for charged β-cyclodextrin.

关 键 词：氯诺昔康 Β-环糊精 溶解度 包合物 

分 类 号：O629.12[理学—有机化学] O626[理学—化学]