惠州地区地中海贫血调查  

Survey of incidence of thalassemia in Huizhou Area

作　　者：巫远忠[1] 余小燕[1] 丁发英 刘瑞玉[1] 林静吟[1] 刘集鸿[1] 余相[1] 

机构地区：[1]惠州市中心人民医院,广东惠州516001 [2]惠州市妇幼保健院,广东惠州516001

出　　处：《中国热带医学》2008年第12期2099-2100,共2页China Tropical Medicine

基　　金：惠州市科学技术局项目(编号:2007Y007)

摘　　要：目的调查惠州地区地中海贫血的患病率及其类型。方法采用美国Helena公司SPIFE快速自动电泳分析系统,对调查对象进行血红蛋白电泳分析。结果在筛查的4877名新生儿中,检出地贫携带者369例,检出率为7.57%,其中α-地贫351例(7.2%),β-地贫3例(0.06%),异常血红蛋白病15例(0.31%);在筛查6020名成人中,检出地贫携带者607例,检出率为10.08%,其中α-地贫64例(1.06%),β-地贫516例,占8.57%,异常血红蛋白27例(0.45%)。结论惠州地区地中海贫血检出率高,大规模开展人群筛查和婚前、产前遗传咨询和诊断,对指导优生优育具有重大意义。Objective To survey the prevalence of thalassemia in Huizhou area. Methods U.S. Helena company＇s SPIFE rapid automatic electrophoresis system was used for performing hemoglobin electrophoresis. Results Among the 4 877 newborns 369 of them were detected as thalassemia carriers with a positive rate of 7.57%. The positive rates of α-Thai, β-Thai and hemoglobinopathy were 7.2% （351/4877）, 0.06% （3/4877） and 0.31% （15/4877）. Among the 6 020 adults deteted 607 of them were thalassemia carriers with a positive rate of 10.08%, inclduing α- Thal, β-Thal and hemoglobinopathy with the positive rates of 1.06% （64/6020）, 8.57% （516/6020）, and 0.45% （27/6020）, respectively. There were totally 10 897 people were detected and 967 thalassemia carriers were detected with a positive rate of 8.96%. Conclusion The incidence of thalassemia is high in HuiZhou area and it is of great significance of conducting large scale screening, premarital health checkup as well ad prenatal and postnatal care.

关 键 词：地中海贫血 检出率 血红蛋白 

分 类 号：R566.61[医药卫生—呼吸系统]