氯丙咪嗪和氟西汀治疗儿童抑郁症的对照研究  

Comparative study of clomipramine and fluoxetine in treatment of child depression

作　　者：梅其霞[1] 杨世华[1] 张天秀[1] 

机构地区：[1]重庆医科大学儿童医院,重庆400014

出　　处：《儿科药学杂志》2008年第6期42-43,共2页Journal of Pediatric Pharmacy

摘　　要：目的:比较氯丙咪嗪和氟西汀治疗儿童抑郁症的疗效和安全性。方法:对130例12～17岁抑郁症儿童分别用氯丙咪嗪和氟西汀治疗8周,在治疗前、治疗2周和治疗8周都用抑郁自评价的量表(SDS)评价疗效,用副反应量表(TESS)评价药物不良反应,χ2检验计算P值。结果:在8周时氟西汀组的有效率(87.7)稍微高于氯丙咪嗪组(83.1),但差异无统计学意义(P>0.05);但是在起效时间上氯丙咪嗪组快于氟西汀组,在2周时氯丙咪嗪组的有效率(38.46)高于氟西汀组(18.46),差异有统计学意义(P<0.05)。两组的药物不良反应都较少且轻微,差异无统计学意义(P>0.05)。结论:氯丙咪嗪和氟西汀治疗儿童抑郁症都疗效明显和安全性较高。Objective ： To compare the efficacy and side effects of clomipramine and fluoxetine in treatment of childhood depression. Methods： One hundred and thirty patients with depression were randomly divided into 2 groups treated with clomipramine and fluoxetine respectively for 8 weeks. The efficacy was evaluated with Self-Rating Depression Scale （SDS） and the side effects were evaluated with treatment symptome scale （TESS）. Results：The effective rate of clomipramine group and fluoxetine group were 83.1% and 87.7% respectively, which had no remarkable differences between the two groups. However, the total effective rate of clomipramine group was significantly higher than that of fluoxetine group after two-week treatment. The side effects of both groups were few and light. Conclusions：Both clomipramine and fluoxetine are effective in treatment of child depression with few side effects.

关 键 词：儿童 抑郁症 氯丙咪嗪 氟西汀 

分 类 号：R749.41[医药卫生—神经病学与精神病学]