PLGA载多柔比星磁性纳米微球的制备与表征  

Preparation and Characterization of Doxorubicin-loaded PLGA Magnetic Nanoparticles

作　　者：董鑫[1] 

机构地区：[1]同济大学纳米与生物高分子材料研究所,上海200092

出　　处：《常熟理工学院学报》2008年第10期43-45,共3页Journal of Changshu Institute of Technology

基　　金：国家自然科学基金(C03030401)资助项目

摘　　要：采用复乳法制备了PLGA载多柔比星磁性纳米微球,并对其形貌、粒径、磁性、包封率、载药量等特性进行了表征.实验结果证明,微球形貌良好,粒径分布在20±5 nm范围内,在乳液中分散均匀,具有一定的磁性,微球包封率为41.2%,载药量为0.4%.微球制备方法简便易行,效果良好,各项特性指标符合药物载体要求,在生物活体癌症靶向治疗中具有潜在应用价值.Doxorubicin-loaded PLGA magnetic nanoparticles were prepared by the double emulsion method. The properties of the nanoparticles such as the morphology, size, magnetism, rate of encapsulation and drug-loading amount were characterized. The results demonstrated that the nanoparticles with magnetism dispersed well in the emulsion. The size of the particles were uniformly distributed in the range of 20±5 nm. The rate of encapsulation and the drug-loading amount were 41.2% and 4%, respectively. The preparation method of the drug-loaded nanoparticles is easy but efficient. The various properties of the particles can meet the need for controlled-released drug carriers. They are good candidates for further development of the targeted anti-cancer treatment of animals and human.

关 键 词：磁性纳米微球 PLGA 多柔比星 复乳法 

分 类 号：R73-3[医药卫生—肿瘤]