普通人群脑出血危险因素的汇总分析  

Meta-Analysis of Risk Factors for Intracerebral Hemorrhage in General Population

作　　者：王红[1] 李震中[1] 方保锋[1] 赵子春[1] 曹翠芳[1] 

机构地区：[1]河北医科大学第二医院神经内科,石家庄050000

出　　处：《国际脑血管病杂志》2008年第10期771-778,共8页International Journal of Cerebrovascular Diseases

摘　　要：目的：探讨普通人群脑出血的危险因素。方法：通过西文生物医学期刊文献数据库（EMCC）、中国医院知识仓库（CHK）、MEDLINE和中国生物医学文献数据库（CBMdisc）检索相关研究。检索词为脑出血、因素、病例对照研究或队列研究。结果：共有8篇文献符合纳入标准且有原始数据。因各研究包含的危险因素在计数和计量方面存在差异，无法合并所有数据。高血压、脑血管病家族史、高盐饮食、饮酒、糖尿病、舒张压增高、收缩压增高、吸烟、鼾症和体质指数（BMI）增高的加权均数差（95％可信区间）分别为5．71（4．00～6．79）、3．54（2．44～5．14）、2．58（1．94～3．43）、2．80（2．29～3．43）、2．78（1．83～4．23）、1．90（1．35～2．70）、17．76（16．60～18．92）、30．43（28．61～32．25）、5．42（5．15～5．70）、1．90（1．34～2．69）、6．88（4．61～10．26）和5．42（5．15～5．70）。以上指标在病例组与对照组之间有显著差异（P均〈0．00001）。结论：脑出血的危险因素包括高血压、脑血管病家族史、高盐饮食、吸烟、饮酒、鼾症、糖尿病、超重、舒张压增高、收缩压增高和BMI增高。Objective： To investigate the risk factors for intracerebral hemorrhage in general population. Methods： The related research was searched through English Medical Current Contents （EMCC）, China Hospital Knowledge Database （CHKD）, MEDLINE, and Chinese Biomedical Literature Database （CBM）. The search terms were intracerebral hemorrhage, factor, and case-control study or cohort study. Results： There were 8 literatures with original data were in accordance with the inclusion criteria. All the data could not be combined because there were some differences in counting and metrology in the risk factors included in all the studies. Hypertension, family history of cerebrovascular disease, high salt diet, alcohol consumption, diabetes mellitus, high diastolic pressure, high systolic pressure, smoking, snoring disease, and increased weighted mean difference of body mass index （BMI） （95% confidence interval） were 5.71 （4.00-6.79）, 3.54 （2.44-5.14）, 2.58 （1.94-3.43）, 2.80 （2.29-3.43）, 2.78 （1.83- 4.23, 1.90 （1.35-2.70）, 17.76 （16.60-18.92）, 30.43 （28.61-32.25）, 5.42 （5.15-5.70）, 1.90 （1. 34-2.69）, 6.88 （4. 61-10.26, and 5.42 （5.15-5.70）, respectively. There were significant differences between the patient groups and control groups among the above indexes （all P 〈 0. 000 01 ）. Conclusions： The risk factors for intracerebral hemorrhage include hypertension, family history of cerebrovascular disease, high salt diet, smoking, alcohol consumption, snoring disease, diabetes mellitus, overweight, high diastolic blood pressure, high systolic blood pressure and increased BMI.

关 键 词：脑出血 汇总分析 危险因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]