长春瑞滨对中晚期食管癌放疗增敏作用的疗效观察  

Observations of low-dose navelbine in sensitization of radiotherapy on intermediate and advanced esophageal carcinoma.

作　　者：李志琳[1] 马家宝[1] 吴双[1] 韦小梅[1] 徐珂[1] 文浩[1] 郎锦义[1] 

机构地区：[1]四川省肿瘤医院放疗科,四川成都610041

出　　处：《四川医学》2008年第11期1485-1487,共3页Sichuan Medical Journal

摘　　要：目的探讨小剂量长春瑞滨同步放化疗对中晚期食管癌的放疗增敏作用。方法将60例不宜手术的中晚期食管癌患者随机分为长春瑞滨增敏放疗组和单纯放疗组各30例,两组放射治疗方法相同,均采用常规设野,常规分割外照射,总剂量60～66Gy,放疗增敏组在放疗同期每周接受1次长春瑞滨6mg/m2化疗,连用6～7周。结果增敏放疗组与单纯放疗组完全缓解率(CR)分别为73.3%和46.7%,(P<0.05),两组1年和3年局部控制率分别为80.7%、54.1%(P<0.05)和70.4%、43.4%(P<0.05)。两组1年无疾病生存率分别为73.8%和46.9%(P<0.05),1年无复发生存率分别为77.0%和50.7%(P<0.05);两组3年无疾病生存率分别为23.5%和16.8%(P>0.05);两组3年无复发生存率分别为30.4%和20.8%(P>0.05);1年生存率分别为76.9%和50.6%(P<0.05),两组3年和5年生存率分别为33.5%、21.0%和13.5%、10.9%(P>0.05),放疗增敏组不良反应可耐受。结论小剂量长春瑞滨作为增敏剂联合放疗治疗中晚期食管癌,能提高患者的局部控制率和近期消退率,不良反应轻微。Objective To evaluate the radiosensitizing effect of low-dose navelbine in treating advanced esophageal carcinoma. Methods 60 patient with unresectable intermediate and advanced esophageal carcinoma were randomized into the radiosenstization group with 30 patients（ RS group） and the simple-radiotherapy group with 30 patients（ RT group）. All patients were given the same radiotherapy {routine fractionation radiotherapy, DT 60 - 66Gy ）. The patients in the RS group were treated with radiotherapy combined with low-dose navelbine 6mg/m^2 weekly for 6 - 7 weeks. The patients in the RT group received radiotherapy alone. Results The response rates（ CR ） for the RS group and the RT group were 73.3 % and 46,7 % （ P 〈 0.05 ）, the 1-year local control rates were 80.7 % and 54.1% （ P 〈 0.0S ） ,3 - year local control rate were 70.4% and 43.4% （ P 〈 0.05） .The 1 - year disease-free survival rate were 73.8% and 46.9% （ P 〈 0. 05 ）, the 1 - year failure-free survival rate were 77.0 % and 50.7 % （ P 〈 0.05 ）, but the 3- year DFS rate and FFS rate were similar. The 1-year survival rates for those two groups were 76.9 % and 50.6 （ P 〈 0.05 ）, but the 3-years ad S-years survival rates were simi- lar. Toxic effects in the RS group was tolerable for all of the patients. Conclusion low-dose navelbi.ne combined with radiotherapy for intermediate and advanced esophageal carcinoma can improve the local control rates and the initial response rates and have slight side effects.

关 键 词：食管癌 放射治疗 化学治疗 

分 类 号：R735.1[医药卫生—肿瘤]