Synthesis of Heterocycle Compounds Containing Two Pyridazinone Units  

作　　者：XIN Bing-wei 

机构地区：[1]Department of Chemistry, Dezhou University, Dezhou 253023, P. R. China

出　　处：《Chemical Research in Chinese Universities》2008年第6期739-742,共4页高等学校化学研究（英文版）

基　　金：Support by the National Natural Science Foundation of China(No.20571063)

摘　　要：Four novel compounds containing two pyridazinone units attached to one benzene or pyridine ring, protected and deprotected 1,5-di[3（2H）-pyridazinon-6-yl]benzene and 2,6-di[3（2H）-pyridazinon-6-yl]pyridine were synthesized in eight steps, which provided a useful method for the preparation of pyridazinone derivatives via the Stetter and cyclization reactions. Their structures were characterized by ^1H NMR, ^13C NMR, and HRMS.Four novel compounds containing two pyridazinone units attached to one benzene or pyridine ring, protected and deprotected 1,5-di[3（2H）-pyridazinon-6-yl]benzene and 2,6-di[3（2H）-pyridazinon-6-yl]pyridine were synthesized in eight steps, which provided a useful method for the preparation of pyridazinone derivatives via the Stetter and cyclization reactions. Their structures were characterized by ^1H NMR, ^13C NMR, and HRMS.

关 键 词：1 5-Di[3（2H）-pyridazinon-6-yl]benzene 2 6-Di[3（2H）-pyridazinon-6-yl]pyridine PYRIDAZINONE Stetter reaction Antitumor compound 

分 类 号：O6[理学—化学]