PYRIDAZINONE

作品数：5被引量：5H指数：1
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相关领域：理学更多>>
相关作者：王腾更多>>
相关机构：中国药科大学更多>>
相关期刊：《Chemical Research in Chinese Universities》《Journal of Chinese Pharmaceutical Sciences》《Acta Pharmaceutica Sinica B》更多>>
相关基金：国家自然科学基金北京市自然科学基金更多>>
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Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors
《Acta Pharmaceutica Sinica B》2021年第3期781-794,共14页Xiaowei Wu Mengdi Dai Rongrong Cui Yulan Wang Chunpu Li Xia Peng Jihui Zhao Bao Wang Yang Dai Dan Feng Tianbiao Yang Hualiang Jiang Meiyu Geng Jing Ai Mingyue Zheng Hong Liu 
financial support from the National Natural Science Foundation of China (81620108027 and21632008 to Hong Liu, 81773634 to Mingyue Zheng and81773762 to Jing Ai);National Science&Technology Major Project “Key New Drug Creation and Manufacturing Program”(2018ZX09711002, China);the Major Project of Chinese National Programs for Fundamental Research and Development(2015CB910304 to Hong Liu);“Personalized Medicinesd Molecular Signature-based Drug Discovery and Development”;Strategic Priority Research Pro-gram of the Chinese Academy of Sciences (XDA12050201 to Mingyue Zheng,XDA12020000 to Meiyu Geng and XDA12020103 to Jing Ai);The Natural Science Foundation of China for Innovation Research Group (81821005 to Meiyu Geng, China);The Collaborative Innovation Cluster Project of Shanghai Municipal Commission of Health and Family Planning (2020CXJQ02 to Meiyu Geng,China)。
Fibroblast growth factor receptors (FGFRs) have emerged as promising targets for anticancer therapy.In this study,we synthesized and evaluated the biological activity of 66 pyrazolo[3,4-d]pyridazinone derivatives.Kina...
关键词：Tyrosine kinase Covalent FGFR inhibitors Virtual screening Pyrazolo[3 4-d]pyridazinone Structure-activity relationships Antitumor efficacy 
Design and synthesis of nitrogen-fused pyridazinone fluorescent probes and their application in biological imaging
《Journal of Chinese Pharmaceutical Sciences》2019年第5期298-315,共18页Hui Liu Lei Liang Lan Yuan Fengrong Xu Yan Niu Chao Wang Ping Xu 
Beijing Natural Science Foundation(Grant No.7162110);Interdisciplinary Medicine Seed Fund of Peking University(Grant No.BMU2018MC004);the National Natural Science Foudation of China(Grant No.201807006,81872731,91630314)
A series of small-molecular fluorescent probes based on nitrogen-fused pyridazinone scaffold were developed in this report.The design strategy involved two steps:1)enhancing the electron-withdrawing ability of the acc...
关键词：Nitrogen-fused pyridazinone Fluorescent probe Biological imaging DESIGN SYNTHESIS 
Synthesis of Heterocycle Compounds Containing Two Pyridazinone Units
《Chemical Research in Chinese Universities》2008年第6期739-742,共4页XIN Bing-wei 
Support by the National Natural Science Foundation of China(No.20571063)
Four novel compounds containing two pyridazinone units attached to one benzene or pyridine ring, protected and deprotected 1,5-di[3（2H）-pyridazinon-6-yl]benzene and 2,6-di[3（2H）-pyridazinon-6-yl]pyridine were synt...
关键词：1 5-Di[3（2H）-pyridazinon-6-yl]benzene 2 6-Di[3（2H）-pyridazinon-6-yl]pyridine PYRIDAZINONE Stetter reaction Antitumor compound 
Synthesis of N-Aryl-2-(1′,6′-dihydro-6′-pyridazinone-3′-carbonyl) Thiosemicarbazides and Their Related Heterocyclic Compounds被引量：5
《Chemical Research in Chinese Universities》2005年第2期172-176,共5页WANGDuo-zhi CAOLing-hua 
theNationalNaturalScienceFoundationofChina(Nos.29962002and20462006).
Dihydro-3-hydrozinocarbonyl-6-pyridazinone(compound 2) were prepared from α-ketoglutaric acid and hydrazine hydrate. A series of N-aryl-2-(1′,6′-dihydro-6′-pyridazinone-3′-carbonyl) thiosemicarbazides 3a_3f were ...
关键词：PYRIDAZINONE 1 3 4-THIADIAZOLE 1 3 4-OXADIAZOLE 1 2 4-Triazol-5-thione Synthesis. 
Synthesis and Electronic Properties of 6-Chloro-2-diethylaminoethyl-3(2H)-pyridazinone
《Chemical Research in Chinese Universities》2003年第1期100-106,共7页ZHOU Zi-yan SU Zhong-min 等 
Supported by the National Natural Science Foundation of China(No. 2 0 16 2 0 0 5 ) .
Chloro 2 diethylaminoethyl 3(2H) pyridazinone was synthesized by the reaction of 6 chloro 3(2H) pyridazinone and 2 diethylamionethyl chloride reaction in methylbenzene. Then the structure was characterized by...
关键词：Chloro  2  diethylaminoethyl  3(2H)  pyridazinone Ab initio DFT Electronic properties 
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