1,3,4-OXADIAZOLE

作品数：69被引量：82H指数：5
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相关作者：段利王鹏程军妍王华林祁争健更多>>
相关机构：山东师范大学东南大学中国科学院大学北京大学更多>>
相关期刊：《Aging Communications》《Science China Chemistry》《Pharmacology & Pharmacy》《Chemical Research in Chinese Universities》更多>>
相关基金：国家自然科学基金山东省优秀中青年科学家科研奖励基金教育部留学回国人员科研启动基金广东省自然科学基金更多>>
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1,3,4-oxadiazole-a bioactive scaffold for treating major depression-associated cognitive dysfunction
《Aging Communications》2023年第2期26-34,共9页Davinder Kumar Virender Kumar Aakash Deep Harsh Kumar Rakesh Kumar Marwaha 
Background:Alzheimer’s disease affects millions of people worldwide,and one of its major characteristics is the accumulation of extracellular Aβpeptides in the human brain,leading to neuronal death and resulting in ...
关键词：1 3 4-OXADIAZOLE Alzheimer’s disease DEMENTIA AMYLOIDS antioxidant properties 
The integration of dinitropyrazole and 1,3,4-oxadiazole:A novel hybrid heterocyclic skeleton for balancing energy and stability被引量：1
《Defence Technology（防务技术）》2023年第6期122-128,共7页Xiao-xiao Zheng Ting-ou Yan Lei Qian Hong-wei Yang Guang-bin Cheng 
support from the National Natural Science Foundation of China[No.22075143,21875110];the Science Challenge Project[TZ2018004];the Qing Lan Project for the grant。
In this study,a new energetic hybrid skeleton was constructed through the integration of nitropyrazole and 1,3,4-oxadiazole skeletons in a molecule.Furthermore,the energetic precursor(2),the azo-bridged compound(3),th...
关键词：HETEROCYCLE Azo-bridged Hybrid skeletons Energetic materials 
1,3,4-Oxadiazole as an emerging telomerase inhibitor-a promising anticancer motif
《Cancer Advances》2022年第18期1-6,共6页Davinder Kumar Virender Kumar Harsh Kumar Aakash Deep Rakesh Kumar Marwaha 
Currently,cancer is the most rapidly growing life-threatening disease after cardiovascular in the world,posing a major threat to human life.Telomerase promotes tumorigenesis and development in most cancers and dyskeri...
关键词：1 3 4-Oxadiazole derivatives telomerase enzyme inhibitors anticancer drugs growth factors 
[4+1]Cyclization of benzohydrazide and ClCF_(2)COONa towards 1,3,4-oxadiazoles and 1,3,4-oxadiazoles-d_(5)被引量：2
《Chinese Chemical Letters》2022年第3期1511-1514,共4页Ya Wang Shiqiang Mu Xin Li Qiuling Song 
Financial support from the National Natural Science Foundation of China(Nos.21772046,2193103);the Guangdong Provincial Key Laboratory of Catalysis(No.2020B121201002);Subsidized Project for Cultivating Postgraduates’Innovative Ability in Scientific Research of Huaqiao University。
A facile synthesis of 1,3,4-oxadiazoles and 1,3,4-oxadiazoles-d_(5) via[4+1]cyclization of ClCF_(2)COONa with non-amine compounds containing amino groups is developed.Of note,this is the first time that halofluorinate...
关键词：Transition-metal-free catalyzed [4+1]Cyclization Halofluorinated compounds 1 3 4-Oxadiazoles 
Synthesis,Crystal Structure and Antifungal Activity of New Furan-1,3,4-oxadiazole Carboxamide Derivatives
《Chinese Journal of Structural Chemistry》2022年第2期98-104,I0010,共8页SUN Yue YANG Zi-Hui GU Wen 
supported by the National Natural Science Foundation of China (31770616);the Natural Science Foundation for Colleges and Universities in Jiangsu Province (17KJA220002)。
A series of novel furan-1,3,4-oxadiazole carboxamide derivatives (5a~5e) were designed,synthesized and characterized by spectroscopic methods including HR-MS,^(1)H-and ^(13)C-NMR.The crystal structure of compound 5a w...
关键词：furan-1 3 4-oxadiazole carboxamide SYNTHESIS crystal structure antifungal activity 
Synthesis,Crystal Structure and DFT Calculation of 2-Methoxyimino Phenylacetate Derivatives Containing 1,3,4-Oxadiazole Ring被引量：1
《Chinese Journal of Structural Chemistry》2021年第12期1647-1654,1554,共9页REN Hui-Dong LI Kang-Ming YI Yang-Jie WANG Man YE Jiao HU Ai-Xi CHEN Yun OU Xiao-Ming LI Jian-Ming 
This project was supported by the National Key R&D Program of China(No.2016YFD0300708)。
Four novel 2-methoxyimino phenylacetate derivatives containing 1,3,4-oxadiazole ring were designed and synthesized from the key intermediate of Trifloxystrobin or Azoxystrobin via intermediate derivatization and activ...
关键词：2-methoxyimino phenylacetate derivatives SYNTHESIS crystal structure fungicidal activities DFT calculation 
Oxadiazole-Functionalized Polyacrylonitrile Fiber as Selective Adsorbent for Mercury Ion被引量：1
《Transactions of Tianjin University》2020年第1期49-56,共8页Liping Hou Minli Tao 
supported by the National Natural Science Foundation of China (Nos.21777111 and 21572156)
A new oxadiazole-functionalized polyacrylonitrile fiber(PANAOF)was successfully fabricated by immobilizing the organic molecule 2-chloromethyl-5-phenyl-1,3,4-oxadiazole on aminated fiber(PANAF).The fibers were charact...
关键词：Polyacrylonitrile fiber MERCURY Adsorption 1 3 4-OXADIAZOLE SELECTIVITY 
Synthesis,in vitro antibacterial and antifungal evaluation of novel 1,3,4-oxadiazole thioether derivatives bearing the 6-fluoroquinazolinylpiperidinyl moiety
《Chinese Chemical Letters》2020年第2期434-438,共5页Jun Shi Na Luo Muhan Ding Xiaoping Bao 
financially supported by Young Top-Notch Talent Support Program of Guizhou Provincial Education Department(No.2018038);Guizhou Provincial High-Level Overseas Talents Innovation and Enterpreneurship Program(No.201809);Breeding Program of Guizhou University(No.20185781)。
A series of structurally novel 1,3,4-oxadiazole thioether derivatives(6a-6z) containing a 6-fluoroquinazolinylpiperidinyl moiety were designed and synthesized using pharmacophore hybrid approach,and their structures w...
关键词：1 3 4-OXADIAZOLE THIOETHER Fluoroquinazolinylpiperidinyl SYNTHESIS Antibacterial ACTIVITY ANTIFUNGAL ACTIVITY 
Synthesis, Crystal Structure and Antitumor Activity of 4-(5-(2,6-Difluorophenyl)-1,3,4-oxadiazol-2-ylthio)-2-(trifluoromethyl)thieno[2,3-d]pyrimidine
《Chinese Journal of Structural Chemistry》2019年第8期1344-1348,共5页SONG Xin-Jian LI Chen-Chen WANG Xu-Mei SUN Qi YANG Ping 
supported by the National Natural Science Foundation of China(No.21262012)
The title compound 4-(5-(2,6-difluorophenyl)-1,3,4-oxadiazol-2-ylthio)-2-(trifluoromethyl)thieno[2,3-d]pyrimidine(C15H5F5N4OS2, Mr = 416.35) was designed and synthesized as antitumor agent, and its structure was deter...
关键词：thieno[2 3-d]pyrimidine 1 3 4-OXADIAZOLE FLUORINATED compound crystal structure ANTITUMOR activity 
Pharmacokinetic evaluation,molecular docking and in vitro biological evaluation of 1,3,4-oxadiazole derivatives as potent antioxidants and STAT3 inhibitors被引量：2
《Journal of Pharmaceutical Analysis》2019年第2期133-141,共9页Rashmin khanam Iram I.Hejazi Syed Shahabuddin Abdul R.Bhat Fareeda Athar 
supported by UGC (University Grant Commission) (F no.- 43-172/2014 (SR))
1, 3, 4-Oxadiazole derivatives(4 a–5 f) were previously synthesized to investigate their anticancer properties.However, studies relating to their antioxidant potential and signal transducer and activator of transcrip...
关键词：1 3 4-oxadiazoles STRUCTURE-ACTIVITY relationship (SAR) Antioxidant activities STAT3 INHIBITORS Molecular docking 
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