1,3,4-Oxadiazole as an emerging telomerase inhibitor-a promising anticancer motif  

作　　者：Davinder Kumar Virender Kumar Harsh Kumar Aakash Deep Rakesh Kumar Marwaha 

机构地区：[1]Department of Pharmaceutical Sciences,Maharishi Dayanand University,Rohtak 124001 Haryana,India [2]Department of Pharmaceutical Sciences,Chaudhary Bansi Lal University,Bhiwani 127021 Haryana,India

出　　处：《Cancer Advances》2022年第18期1-6,共6页TMR肿瘤进展

摘　　要：Currently,cancer is the most rapidly growing life-threatening disease after cardiovascular in the world,posing a major threat to human life.Telomerase promotes tumorigenesis and development in most cancers and dyskerin plays a crucial role in telomere maintenance.Cancer molecules are being developed continuously as a result of continuous research.A series of novel anticancer agents have been developed using telomerase inhibitors with improved specificity and pharmacokinetics.As medicinal chemistry advances,heterocyclic-based drugs find increasing applications,including anticancer agents.These properties have led to the development of five-membered aromatic rings of oxadiazoles.In order to enhance their anticancer activity,oxadiazole scaffolds can be modified.In this review,we discuss the functions and mechanism of action of the telomerase enzyme.The paper also summarizes the interaction between 1,3,4-oxadiazole inhibitors and telomerase enzymes.

关 键 词：1 3 4-Oxadiazole derivatives telomerase enzyme inhibitors anticancer drugs growth factors 

分 类 号：R73[医药卫生—肿瘤]