Synthesis of N-Aryl-2-(1′,6′-dihydro-6′-pyridazinone-3′-carbonyl) Thiosemicarbazides and Their Related Heterocyclic Compounds  

作　　者：WANGDuo-zhi CAOLing-hua 

机构地区：[1]DepartmentofChemistry,XinjiangUniversity,Urumqi830046,P.R.China [2]DepartmentofChemistry,XinjiangUniversity,Urumqi830046,P.R.China／／StateKeyLaboratoryofElemento-organicChemistry,NankaiUniversity,Tianjin300071,P.R.China

出　　处：《Chemical Research in Chinese Universities》2005年第2期172-176,共5页高等学校化学研究（英文版）

基　　金：theNationalNaturalScienceFoundationofChina(Nos.29962002and20462006).

摘　　要：Dihydro-3-hydrozinocarbonyl-6-pyridazinone(compound 2) were prepared from α-ketoglutaric acid and hydrazine hydrate. A series of N-aryl-2-(1′,6′-dihydro-6′-pyridazinone-3′-carbonyl) thiosemicarbazides 3a_3f were synthesized from the reaction of aryl isothiocyanates with compound 2. The terminal compounds 1,3,4-thiadiazole, 1,3,4-oxadiazole and 1,2,4-triazol-5-thione derivatives were cyclized from compounds 3a_3f. Their structures were confirmed by IR, 1H NMR, MS and elemental analyses.Dihydro-3-hydrozinocarbonyl-6-pyridazinone(compound 2) were prepared from α-ketoglutaric acid and hydrazine hydrate. A series of N-aryl-2-(1′,6′-dihydro-6′-pyridazinone-3′-carbonyl) thiosemicarbazides 3a_3f were synthesized from the reaction of aryl isothiocyanates with compound 2. The terminal compounds 1,3,4-thiadiazole, 1,3,4-oxadiazole and 1,2,4-triazol-5-thione derivatives were cyclized from compounds 3a_3f. Their structures were confirmed by IR, 1H NMR, MS and elemental analyses.

关 键 词：PYRIDAZINONE 1 3 4-THIADIAZOLE 1 3 4-OXADIAZOLE 1 2 4-Triazol-5-thione Synthesis. 

分 类 号：O626[理学—有机化学]