吗啡不同剂量和给药时程对建立大鼠条件性位置偏爱模型的影响  

The effects of different doses and different lengths of morphine in the formation of rats' conditioned place preference(CPP)model

作　　者：邵晓霞[1] 赵永娜[1] 李顺英[1] 杨贞永[1] 

机构地区：[1]昆明医学院药学院药物毒理学教研室,昆明650031

出　　处：《中国药物滥用防治杂志》2008年第6期326-329,共4页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：云南省应用基础研究计划面上项目(2006C0037Q)

摘　　要：目的:比较吗啡不同给药剂量及不同给药时程对建立大鼠条件性位置偏爱(CPP)模型的影响,用于建立滿意的CPP模型。方法:分别采用15mg/kg吗啡连续颈背部皮下注射(SC)6d,10mg/kg吗啡连续颈背部皮下注射(SC)6d、8d、10d进行CPP训练,测定大鼠在伴药箱停留的时间。结果:与对照组比较,15mg/kg吗啡6d组、10mg/kg吗啡8d组和10mg/kg吗啡10d组大鼠在伴药箱停留的时间均明显延长(P<0.05),诱导大鼠CPP建立,三组大鼠在伴药箱停留时间比较差异无统计学意义;10mg/kg吗啡训练大鼠6d后,与相应的生理盐水对照组比较,大鼠在伴药箱停留时间差异无统计学意义,未能诱导CPP形成。结论:大鼠在用10mg/kg吗啡训练8d、10d及15mg/kg吗啡训练6d后,均可诱导大鼠CPP形成,但10mg/kg吗啡训练8d建立的CPP模型较滿意。Objective： To compare the effects of different doses and different lengths of morphine injections in the formation of conditioned place preference （CPP）, and then establish ideal CPP model in rats. Methods： Rats received subcutaneous （s.c.） injections of morphine 10mg/kg for 6 days and 15 mg/kg respectively 6 days, 8 days and 10 days to induce conditioned place preference, the time spent in the drug-paired compartment was observed. Results： Compared with the corresponding control groups, the time spent in the drug-paired compartment increased significantly in group 10 mg/kg8d, 10 mg/kg10d and 15 mg/kg6d, moreover there were no significant differences in the time spent in the drug-paired compartment among the three groups. After 6 days training with constant 10 mg/kg injection of morphine, CPP failed to be induced. Conclusion： Constant injections of morphine （10 mg/kg, 15 mg/kg） conditioning for 8 days, 10 days and 6 days succeeded to induce CPP, but morphine （10mg/kg） 8 days may establish more ideal CPP model.

关 键 词：条件性位置偏爱模型 吗啡 大鼠 

分 类 号：R-332[医药卫生]