射频深部热疗中金属支架对猪食管黏膜的损伤(英文)  

Damage to pig esophageal mucosa caused by metal stent in radiofrequency hyperthermia

作　　者：陈玉林[1] 吴敬波[2] 宿向东[1] 谭燕琼[2] 范娟[2] 文庆莲[2] 黄镇东[1] 

机构地区：[1]乐山市人民医院肿瘤科,四川省乐山市614000 [2]泸州医学院附属医院肿瘤科,四川省泸州市646000

出　　处：《中国组织工程研究与临床康复》2008年第44期8775-8778,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：背景:热疗在食管癌综合治疗中取得了明显的疗效,放置食管金属支架后的食管癌患者,能否进行深部热疗尚不清楚。目的:实验拟观察射频深部热疗中金属支架对猪食管黏膜的损伤程度。设计、时间及地点:观察性实验,于2004-10/2005-01在泸州医学院附属医院肿瘤科完成。材料:取普通肉猪13只,体质量35～40kg。记忆合金带膜食管支架,由常州市智业医疗仪器研究所提供。方法:采用SR-1000射频深部热疗机对放置金属支架的13只猪食管进行体外加热。在金属支架上缘上4cm、支架中心处、支架下缘处、支架下缘下2cm处和支架下缘下4cm处的食管黏膜处分别设置5个观察点。频率40.82MHz,极板25cm×25cm,功率500～700W;加热30min。主要观察指标:肉眼观察5个观察点食管黏膜的损伤情况,并取5个观察点处的食管黏膜作病理学检查。结果:纳入普通肉猪13只,实验过程1只猪死于麻醉,4只猪的测温线出现故障。8只猪进入结果分析。①8只猪40个观察点处的食管黏膜肉眼损伤程度为0～1级,经统计学等级资料的秩和检验H=2.734,各观察点损伤程度相比,差异无显著性意义(P=0.255)。②显微镜下显示食管粘膜损伤程度为0～2级,经统计学等级资料的秩和检验H=2.734,各观察点损伤程度相比,差异无显著性意义(P=0.255)。结论:在射频深部热疗中,食管金属支架置入本身不引起明显的食管黏膜机械性损伤,亦不加重食管黏膜的热损伤,金属内支架置入后行射频深部热疗在近期是安全可行的。BACKGROUND： Thermotherapy has achieved remarkable therapeutic effect on patients with esophageal cancer. However, there are still some problems which cannot be answered today, such as the damage of esophageal mucosa during deep thermotherapy when metal stent is placed in esophagus. OBJECTIVE： To study the metal stent-caused damages to esophageal mucosa of pigs in radiofrequency hyperthermia. DESIGN, TIME AND SETTING： Observational study which was performed in the Department of Tumor, Affiliated Hospital of Luzhou Medical College from October 2004 to January 2005. MATERIALS： 13 pigs weighing 35 40 kg were used in this study. Esophagus stent of memory alloy with membrane was provided by Zhiye Medical Apparatus Institute of Changzhou, China METHODS： Five points were located for measurement, i.e. the middle of the stent, the exit of the stent, 2 cm and 4 cm a distance from the exit and 4 cm from the entrance. Esophagus of 13 pigs was heated for 30 minutes by SR-1000 radiofrequency hyperthermia machine in frequency of 40.82 MHz, pole plate of 25 cm × 25 cm and power of 500 700 W. MAIN OUTCOME MEASURES： The esophageal mucosa was observed with naked eyes. And optical microscopy was used to observe the changes of the esophageal mucosa. RESULTS： Because one pig died of anesthesia and there were troubles of thermal detector lines in 4 pigs, only 8 pigs were included in the final analysis. Level of damage of esophageal mucosa on five temperature checkpoims was observed from grade 0 to 1 in naked eyes, and the difference of damaged level between five checkpoints was not obvious in statistics （H=2.0, P=0.157）. Level of the damage was observed from grade 0 to 2 in microscope, and the difference was not obvious in statistics too （H=2.734, P=0.255）. CONCLUSION： Influence of the metal stent on esophageal mucosa can be neglected in radiofrequency hyperthermia, and metal stent does not cause obvious mechanical damage or thermal damage to esophageal mucosa of pigs. It is safe and feasible to ca

关 键 词：射频热疗 金属支架 食管黏膜 猪 

分 类 号：R571[医药卫生—消化系统]