中晚期鼻咽癌放化疗综合治疗临床观察  

Comprehensive therapy for advanced nasopharyngeal carcinoma

作　　者：王朝霞 

机构地区：[1]芜湖市弋矶山医院放疗科,安徽芜湖241000

出　　处：《现代肿瘤医学》2008年第12期2079-2081,共3页Journal of Modern Oncology

摘　　要：目的:探讨DF方案联合治疗中晚期鼻咽癌的临床价值。方法:将65例中晚期鼻咽癌患者随机分成两组。一组35例行放射治疗配合DF方案化疗(综合组)。另一组30例行单纯放射治疗(单放组)。放射治疗采用6MV-X和电子线常规照射,剂量60-70Gy;化疗在放射前后一到两个星期内,按3周行一周期。两组均随访5年。结果:综合组与单放组5年生存率和局部控制率分别为62.9、36.7和77.1、53.3。综合组5年生存率和局部控制率均明显高于单放组,且两者有显著差异(P<0.05),而毒副反应相仿。结论:放射治疗中晚期鼻咽癌配合DF化疗方案疗效较好,值得临床进一步应用。Objective： To study the therapeutic effect of chemotherapy with DF regimen after radiotherapy for naso- pharyngeal cancer. Methods ： A prospective randomized trial on chemotherapy with DF regimen after radiotherapy for n asopharyngeal neoplasms was carried, 65 patients were randomized into combined group（ R ＋ C,35 patients） or ra- diotherapy alone group （R ,30 patients） 6MV -X 12Mev - 13and 9Mev - 13 were used for all patients, to deliver60 - 70Gy, chemotherapy was given every 3 weeks for 1 cycles before radiotherapy and for 2 - 3 cycles after radiotherapy in R ＋ C group. Both groups were followed for 5 years. Results： Five year local control rate were 77. 1% in R ＋ C group and 53.3% in R group, the survival rate was 62.9% in R ＋ C group and 36.7% in R group （ P 〈0.05）. The side reaction of patients was similar. Conclusion： Chemotherapy with DF regimen after radiotherapy for nasopharygeal neoplasms has good effect.

关 键 词：鼻咽肿瘤 放射治疗 药物治疗 综合治疗 

分 类 号：R739.63[医药卫生—肿瘤]