乳腺浸润性导管癌组织中HPV18 DNA及p53蛋白的表达  

Expression of HPV18 DNA and p53 protein in mammary invasive duct carcinomas

作　　者：黄平[1] 任占平[1] 

机构地区：[1]广西柳州市人民医院普通外科,广西柳州545001

出　　处：《现代肿瘤医学》2008年第12期2090-2091,共2页Journal of Modern Oncology

基　　金：广西卫生厅医疗卫生科研课题项目(No.Z2004094)

摘　　要：目的:探讨人乳腺浸润性导管癌组织中HPV18DNA和p53蛋白的表达及二者间的关系。方法:采用分子原位杂交和免疫组化技术检测60例乳腺浸润性导管癌、30例乳腺腺病和30例正常乳腺组织中HPV18DNA和p53蛋白。结果:癌组中HPV18DNA阳性和HPV18DNA阴性两组间p53蛋白的阳性表达均有显著性差异(P<0.03),HPV18DNA阳性组与p53蛋白阳性表达呈显著负相关(r=-0.2954、P<0.04)。结论:HPV18感染后导致野生型p53的灭活和降解可能涉及HPV18感染后人乳腺上皮细胞癌变的转化过程。Objective ：To investigate the expression of HPV18 DNA and p53 protein in breast cancer and explore its relation between expression of HPV18 infection with p53 and the carcinogenesis of breast cancer. Methods： HPV18 DNA and p53 protein were detected by in situ hybridization and staining in 60 cases of invasive duct carcinoma ,30 case of breast diseases and 30 cases of normal breast tissues. Results： There was a sig- nificant difference in the expression of p53 protein between HPV18 DNA positive and HPV18 DNA negative breast carcinomas groups （P 〈 0.03） , HPV18 positive expression was inversely correlated with p53 protein expression in carcinoma groups（r = -0. 2954,P 〈 0.04）. Conclusion： Inactivation and degradation of wild type p53 protein by HPV18 infection in hamann mammary epithelial cells may play an important role in the pathogenesis of haman breast carcinomas.

关 键 词：乳腺肿瘤 人乳头瘤病毒 原位杂交 P53蛋白 

分 类 号：R737.9[医药卫生—肿瘤]